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Abelacimab (anti-Factor XI) - Primary antibody, specific to F11, >95%, high purity, Human IgG1, Antibody of integrin αIIbβ3, Antibody of integrin αIIbβ3

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175444
Grouped product items
SKU Size
Availability
 Price Qty
Ab175444-100μg
100μg
10
$59.90
Ab175444-1mg
1mg
4
$299.90
Ab175444-5mg
5mg
1
$599.90
Ab175444-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$969.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: F11 Click to view target information: ITGA2B Click to view target information: ITGB3
Accession#:P03951 (2) Amino Acid/Protein Metabolism (1836) coagulation factor XI Antibody (2) F11 (2) Factor XI (2) Gene ID:2160 (2)

Basic Description

Product Name Abelacimab (anti-Factor XI) - Primary antibody, specific to F11, >95%, high purity, Human IgG1, Antibody of integrin αIIbβ3
Synonyms coagulation factor XI antibody | Coagulation factor XIa light chain antibody | F11 antibody | FA11_HUMAN antibody | FXI antibody | MGC141891 antibody | Plasma thromboplastin antecedent antibody | Platelet coagulation factor XI antibody | PTA antibody | Co
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Host species Human
Specificity F11
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of integrin αIIbβ3
Product Description

Abelacimab (anti-Factor XI) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab (anti-Factor XI) can be used in thromboembolic disease studies.

Product Properties

Isotype Human IgG1
Light Chain Type lambda
SDS-PAGE 27.4 kDa (Light Chain) & 50.4 kDa (Heavy Chain), under reducing conditions; 197.4kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2098724-83-3

Associated Targets(Human)

F11 Tchem Coagulation factor XI (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGA2B Tclin Integrin alpha-IIb (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGB3 Tclin Integrin beta-3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGA2B Tclin Integrin alpha-IIb (36 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
F11 Tchem Coagulation factor XI (1733 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-V/beta-3 (2708 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-IIb/beta-3 (3481 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) (39 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-V/beta-3 and alpha-IIb/beta 3 (49 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-2/beta-3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-3/beta-3 (47 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Abelacimab (anti-Factor XI) (Ab175444) - SEC
The purity of Abelacimab (anti-Factor XI) (Ab175444) is more than 95% verified by HPLC.

Abelacimab (anti-Factor XI) (Ab175444) - ELISA
Immobilized Human F11-his at 2.0 μg/mL can bind Abelacimab (anti-Factor XI) (Ab175444) with the EC₅₀ of 31.79 ng/mL.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
ZJ24F0607383 Certificate of Analysis Jun 26, 2024 Ab175444
ZJ24F0202895 Certificate of Analysis Mar 01, 2024 Ab175444
ZJ24F0202894 Certificate of Analysis Mar 01, 2024 Ab175444
ZJ24F0202893 Certificate of Analysis Mar 01, 2024 Ab175444

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