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5-Aminofluorescein - 96%, high purity , CAS No.3326-34-9

    Grade & Purity:
  • ≥96%
In stock
Item Number
A110141
Grouped product items
SKU Size
Availability
Price Qty
A110141-250mg
250mg
4
$28.90
A110141-1g
1g
4
$94.90
A110141-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$427.90

Fluorescence marker

Basic Description

Synonyms Fluoresceinamine, isomer 1 | Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-amino-3',6'-dihydroxy- | fluorescein-5-amine | EX-A1779 | Fluoresceinamine isomer 1 | SCHEMBL220211 | 5-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one |
Specifications & Purity ≥96%
Biochemical and Physiological Mechanisms Fluorescence marker. Selectively targets malignant glioma tissue in vivo when covalently linked to human serum albumin at a molar ratio of 1:1without bleaching nor penetrating into surrounding brain edema or necrotic tissue. Blood-brain barrier permeable.
Storage Temp Argon charged
Shipped In Normal
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Fluoresceinamine, isomer I is a building block for synthesis of fluorescein.
A reagent for fluorescence studies

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Benzopyrans
Subclass 1-benzopyrans
Intermediate Tree Nodes Dibenzopyrans
Direct Parent Xanthenes
Alternative Parents Diarylethers  Phthalides  Benzofuranones  Isobenzofurans  1-hydroxy-2-unsubstituted benzenoids  Lactones  Carboxylic acid esters  Amino acids and derivatives  Oxacyclic compounds  Monocarboxylic acids and derivatives  Primary amines  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Xanthene - Diaryl ether - Benzofuranone - Phthalide - Isobenzofuranone - Isocoumaran - Isobenzofuran - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Carboxylic acid ester - Lactone - Amino acid or derivatives - Monocarboxylic acid or derivatives - Ether - Carboxylic acid derivative - Oxacycle - Primary amine - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic nitrogen compound - Organic oxygen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
External Descriptors Not available

Names and Identifiers

IUPAC Name 6-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
INCHI InChI=1S/C20H13NO5/c21-10-1-4-14-13(7-10)19(24)26-20(14)15-5-2-11(22)8-17(15)25-18-9-12(23)3-6-16(18)20/h1-9,22-23H,21H2
InChIKey GZAJOEGTZDUSKS-UHFFFAOYSA-N
Smiles C1=CC2=C(C=C1N)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
Isomeric SMILES C1=CC2=C(C=C1N)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
WGK Germany 3
Molecular Weight 347.32
Beilstein 48395
Reaxy-Rn 48395
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=48395&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number Certificate Type Date Item
F2130051 Certificate of Analysis Apr 09, 2025 A110141
F2130052 Certificate of Analysis Apr 03, 2025 A110141
G2216122 Certificate of Analysis May 30, 2022 A110141
B2325307 Certificate of Analysis May 30, 2022 A110141
G2216112 Certificate of Analysis May 30, 2022 A110141
B2325306 Certificate of Analysis May 27, 2021 A110141
C2210084 Certificate of Analysis May 27, 2021 A110141
B2527323 Certificate of Analysis May 27, 2021 A110141

Chemical and Physical Properties

Solubility Soluble in water (partly), methanol (10 mg/ml), and acetone.
Sensitivity Hygroscopic,Heat & light sensitive.
Melt Point(°C) 223℃
Molecular Weight 347.300 g/mol
XLogP3 2.700
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 0
Exact Mass 347.079 Da
Monoisotopic Mass 347.079 Da
Topological Polar Surface Area 102.000 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 557.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Yang Yimeng, Chao Danming.  (2020)  Electrochromic and Electrofluorochromic Performance of Novel Polysiloxane bearing Tetraaniline and Fluorescein Groups.  International Journal of Electrochemical Science,  15  (9245). 
2. Qian Li, Jing Yang, Wenzhan Yu, Liqiong He, Renlong Zhou, Changming Nie, Lifu Liao, Xilin Xiao.  (2023)  Two Fe(III)/Eu(III) Salophen complex-based optical sensors for determination of organophosphorus pesticide monocrotophos.  Analytical Methods,  15  (19): (2334-2342). 
3. Huitong Luo, Zetao Wang, Zhichao He, Zemin Ling, Hao Wang, Jiayi Zhu, Jingjun Nie, Dafu Chen, Qi Feng, Xiaodong Cao.  (2023)  Injectable chondroitin sulfate-grafted self-antioxidant hydrogels ameliorate nucleus pulposus degeneration against overactive inflammation.  Biomaterials Science,  11  (10): (3629-3644). 
4. Xin Liu, Fan Wang, Li Liu, Tiantian Li, Xiangyu Zhong, Hongsheng Lin, Yi Zhang, Wei Xue.  (2023)  Functionalized polydopamine nanospheres as in situ spray for photothermal image-guided tumor precise surgical resection.  BIOSENSORS & BIOELECTRONICS,  222  (114995). 
5. Hua Pan, Weilan Huang, Litao Wu, Qihao Hong, Zhongxuan Hu, Meijing Wang, Fang Zhang.  (2022)  A pH Dual-Responsive Multifunctional Nanoparticle Based on Mesoporous Silica with Metal-Polymethacrylic Acid Gatekeeper for Improving Plant Protection and Nutrition.  Nanomaterials,  12  (4): (687). 
6. Liu Yipeng, Li Bingyan, Zhang Huixia, Liu Yong, Xie Ping.  (2022)  Detection of Microcystin-LR in the Cells and Natural Lake Water Samples by A Unique Fluorescence-Based Method.  JOURNAL OF FLUORESCENCE,  32  (2): (505-519). 
7. Dongxu Lan, Yulian Shang, Hongxian Su, Minhua Liang, Yang Liu, Haofei Li, Qi Feng, Xiaodong Cao, Hua Dong.  (2021)  Facile Fabrication of Hollow Hydrogel Microfiber via 3D Printing-Assisted Microfluidics and Its Application as a Biomimetic Blood Capillary.  ACS Biomaterials Science & Engineering,  (10): (4971–4981). 
8. Qidi Zhang, Ming Zou, Wanyu Wang, Jinyan Li, Xiao Liang.  (2021)  Design, Synthesis, and Characterization of Tracers and Development of a Fluorescence Polarization Immunoassay for Rapid Screening of 4,4′-Dinitrocarbanilide in Chicken Muscle.  Foods,  10  (8): (1822). 
9. Peifei Wang, Songbai Liu.  (2020)  Development of a Gemini Interfacial Antioxidant for Oil in Water Emulsion with Gallic Acid and Dodecyl Gemini Chains.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  68  (37): (9953–9960). 
10. Aiyun Liu, Huaisong Wang, Xiaoshuang Hou, Yu Ma, Gongjun Yang, Yanglong Hou, Ya Ding.  (2020)  Combinatory antitumor therapy by cascade targeting of a single drug.  Acta Pharmaceutica Sinica B,  10  (667). 
11. Shanshan Wang, Shanshan Wu, Songbai Liu.  (2019)  Integration of (+)-catechin and β-sitosterol to achieve excellent radical-scavenging activity in emulsions.  FOOD CHEMISTRY,  272  (596). 
12. Qiuju Li, Anan Sun, Yinsong Si, Min Chen, Limin Wu.  (2017)  One-Pot Synthesis of Polysaccharide–Diphenylalanine Ensemble with Gold Nanoparticles and Dye for Highly Efficient Detection of Glutathione.  CHEMISTRY OF MATERIALS,  29  (16): (6758–6765). 
13. Wei Xu, Ran Guan, Fushan Shi, Aifang Du, Songhua Hu.  (2017)  Structural analysis and immunomodulatory effect of polysaccharide from Atractylodis macrocephalae Koidz. on bovine lymphocytes.  CARBOHYDRATE POLYMERS,  174  (1213). 
14. Hongying Su, Qingming Jia, Shaoyun Shan.  (2016)  Synthesis and characterization of Schiff base contained dextran microgels in water-in-oil inverse microemulsion.  CARBOHYDRATE POLYMERS,  152  (156). 
15. Yan Yang, Yingjie Lei, Xinrong Zhang, Sichun Zhang.  (2016)  A ratiometric strategy to detect hydrogen sulfide with a gold nanoclusters based fluorescent probe.  TALANTA,  154  (190). 
16. Yuxiu Xing , Jun Peng , Kai Xu, Weihong Lin , Shuxi Gao , Yuanyuan Ren , Xuefeng Gui , Shengyuan Liang , Mingcai Chen.  (2016)  Polymerizable Molecular Silsesquioxane Cage Armored Hybrid Microcapsules with In Situ Shell Functionalization.  CHEMISTRY-A EUROPEAN JOURNAL,  22  (6): (2114-2126). 
17. Wenhua Li, Yurong Cai, Qiwei Zhong, Ying Yang, Subhas C. Kundu, Juming Yao.  (2015)  Silk sericin microcapsules with hydroxyapatite shells: protection and modification of organic microcapsules by biomimetic mineralization.  Journal of Materials Chemistry B,  (2): (340-347). 
18. Xingwang Zhang, Tianpeng Zhang, Yanghuan Ye, Huaqing Chen, Hua Sun, Xiaotong Zhou, Zhiguo Ma, Baojian Wu.  (2015)  Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112 (a Hsp90 inhibitor) with enhanced antitumor effect.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,  94  (30). 
19. Yuliang Xiao, Pingli Li, Yanna Cheng, Xinke Zhang, Juzheng Sheng, Decai Wang, Juan Li, Qian Zhang, Chuanqing Zhong, Rui Cao, Fengshan Wang.  (2014)  Enhancing the intestinal absorption of low molecular weight chondroitin sulfate by conjugation with α-linolenic acid and the transport mechanism of the conjugates.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  465  (143). 
20. Yuanying Li, Han Shao, Yunxiu Zhang, Qiang Liu, Changhan Yan, Xiyin Liu, Yaolan Tao, Renhao Nie, Jianhong Zhang, Qingyan Jia, Peng Li.  (2025)  Extracellular barrier via in situ cross-linked catechol for blocking tumor mass transport and synergistic chemotherapy.  CHEMICAL ENGINEERING JOURNAL,  506  (159880). 
21. Yajing Yang, Fenglin Li, Dayin Sun, Yilan Ye, Zhenzhong Yang.  (2024)  Large-Scale Synthesis of Reactive Janus Inorganic/Polymer Colloidal Dimer.  MACROMOLECULES,  57  (3): (880-886). 
22. Shuqin Wang, Yuejun Yao, Liang Song, Zihe Zhai, Shifen Li, Zhaolong Wang, Liyin Shen, Yang Zhu, Wenxing Liu, Changyou Gao.  (2024)  ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction.  BIOMATERIALS,    (122534). 
23. Yuan Xu, Xin An, Lei Liu, Xinran Cao, Zhanfeng Wu, Wang Jia, Jiacheng Sun, Haoyu Wang, Jiawei Huo, Zihao Sun, Mingming Zhen, Chunru Wang, Chunli Bai.  (2024)  Self-Cascade Redox Modulator Trilogically Renovates Intestinal Microenvironment for Mitigating Endotoxemia.  ACS Nano,  18  (3): (2131-2148). 
24. Chang Guo, Xiaoyao Xiong, Xinxing Zhao, Yumin Li, Sijia Li, Suying Xu, Tony D. James, Leyu Wang.  (2024)  Superhydrophilic Fluorinated Polymer Probe for Zero-Background 19F MRI with Adaptable Targeting Ability.  ACS Applied Materials & Interfaces,  16  (47): (65319-65327). 

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