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1-Deoxynojirimycin - analytical standard,≥98%, high purity , CAS No.19130-96-2, Inhibitor of alpha glucosidase

4 Citations COA COA
In stock
Item Number
D101242
Grouped product items
SKU Size
Availability
 Price Qty
D101242-10mg
10mg
4
$343.90
D101242-20mg
20mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$515.90
D101242-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,026.90
D101242-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,527.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent α-glycosidase inhibitor. Antihyperglycemic agent.

View related series
alpha glucosidase Inhibitor (3) Glucose Metabolism (1943) Glucosidase (71) Metabolic Enzyme/Protease (4860) PI3K (243) PI3K/Akt/mTOR (765)

Basic Description

Synonyms (2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol | (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol | (+)-1-Deoxynojirimycin | 1,5-Dideoxy-1,5-imino-D-sorbitol | DNJ
Specifications & Purity Moligand™, analytical standard, ≥98%
Biochemical and Physiological Mechanisms Potent α-glycosidase inhibitor (IC 50 = 30 nM). Antihyperglycemic agent. Downregulates SGLT1, Na + /K + -ATP and GLUT2 expression. Decreases MCP-1 and TNF-α levels. Shows antidiabetic, antiviral, antiobesity and anti-inflammatory effects in vivo. Orally a
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade analytical standard, Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of alpha glucosidase
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Deoxynojirimycin is a Maltase-glucoamylase (α-glucosidase I and II) inhibitor. Interferes with N-linked glycosylation. Reported to inhibit trimming of oligosaccharides upon treatment of secretory glycoprotein IgD- and IgM-producing cells. Reported to inhibit secretion of IgD. Deoxynojirimycin is an inhibitor of β-glucosidase and Maltase-glucoamylase.
An inhibitor of α-glucosidase I and II

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Piperidines
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Piperidines
Alternative Parents Secondary alcohols  1,2-aminoalcohols  Polyols  Dialkylamines  Azacyclic compounds  Primary alcohols  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular Framework Aliphatic heteromonocyclic compounds
Substituents Piperidine - 1,2-aminoalcohol - Secondary alcohol - Secondary aliphatic amine - Polyol - Secondary amine - Azacycle - Primary alcohol - Alcohol - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organopnictogen compound - Amine - Hydrocarbon derivative - Aliphatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as piperidines. These are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms.
External Descriptors 2-(hydroxymethyl)piperidine-3,4,5-triol

Associated Targets(Human)

GAA Tclin Lysosomal alpha-glucosidase (4 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MGAM Tclin Maltase-glucoamylase, intestinal (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
GANAB Tchem Neutral alpha-glucosidase AB (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MGAM Tclin Maltase-glucoamylase (654 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGCG Tclin Ceramide glucosyltransferase (308 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLB1 Tchem Beta-galactosidase (339 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GANAB Tchem Neutral alpha-glucosidase AB (90 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GANC Tchem Neutral alpha-glucosidase C (4 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TREH Tchem Trehalase (5 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
JAK1 Tclin Tyrosine-protein kinase JAK1 (8569 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NAGA Tbio Alpha-galactosidase B (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR1H3 Tchem LXR-alpha (2891 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MANBA Tchem Beta-mannosidase (62 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FUCA1 Tchem Alpha-L-fucosidase I (304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAN2B1 Tchem Lysosomal alpha-mannosidase (172 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA2 Tchem Beta-glucosidase (258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA3 Tbio Beta-glucosidase cytosolic (63 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SI Tchem Sucrase-isomaltase (84 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FUT10 Tdark Fucosyltransferase 10 (23 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAN2B2 Tbio Epididymis-specific alpha-mannosidase (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR1H2 Tchem LXR-beta (3841 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BGC-823 (3035 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MT4 (17854 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HUVEC (11049 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PBMC (10003 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AGL Tbio Glycogen debranching enzyme (27 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LCT Tbio Lactase-phlorizin hydrolase (37 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC1937 (423 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MS-1 (160 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MGAM Tclin Alpha glucosidase (860 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Gusb Beta-glucuronidase (17 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GAA Alpha-glucosidase (25 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Lct Lactase-glycosylceramidase (87 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Man2a1 Mannosidase 2 alpha 1 (15 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Man2c1 Alpha-mannosidase 2C1 (19 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Man2b1 Mannosidase 2, alpha B1 (9 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gaa Acidic alpha-glucosidase (551 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
bglA Beta-glucosidase A (127 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
aglC Alpha-galactosidase C (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAL62 Alpha-glucosidase MAL62 (106 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
melA Alpha-galactosidase (10 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Man1 Alpha-mannosidase (188 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FUCA1 Alpha-L-fucosidase 1 (358 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IMA1 Oligo-1,6-glucosidase (218 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Glucosylceramidase (58 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCGR Uncharacterized protein (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
INCHI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey LXBIFEVIBLOUGU-JGWLITMVSA-N
Smiles C1C(C(C(C(N1)CO)O)O)O
Isomeric SMILES C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O
Molecular Weight 163.17
Reaxy-Rn 13313614
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13313614&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
J2217445 Certificate of Analysis Jul 17, 2024 D101242
J2217436 Certificate of Analysis Jul 17, 2024 D101242
F2223192 Certificate of Analysis Mar 20, 2024 D101242
J2326208 Certificate of Analysis Oct 11, 2023 D101242
J2326039 Certificate of Analysis Oct 11, 2023 D101242
J2326040 Certificate of Analysis Oct 11, 2023 D101242
J2217437 Certificate of Analysis Sep 26, 2022 D101242
B2216220 Certificate of Analysis Jan 10, 2022 D101242
B2216221 Certificate of Analysis Jan 10, 2022 D101242
B2216222 Certificate of Analysis Jan 10, 2022 D101242

Chemical and Physical Properties

Solubility Soluble in water (25 mg/ml), and methanol., Soluble in water (25 mg/ml), and methanol.
Sensitivity Air sensitive
Molecular Weight 163.170 g/mol
XLogP3 -2.300
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 1
Exact Mass 163.084 Da
Monoisotopic Mass 163.084 Da
Topological Polar Surface Area 93.000 Ų
Heavy Atom Count 11
Formal Charge 0
Complexity 132.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. 1-Deoxymannojirimycin hydrochloride
    1-Deoxymannojirimycin hydrochloride
    • ≥98%

    Starting at $52.90

  2. α-Homonojirimycin
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    Starting at $638.90

  3. 1-Deoxynojirimycin hydrochloride
    1-Deoxynojirimycin hydrochloride
    • ≥98%

    Starting at $68.90

  4. 1-Deoxynojirimycin, Inhibitor of alpha glucosidase
    1-Deoxynojirimycin, Inhibitor of alpha glucosidase

    Starting at $114.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Xinlin Chen, Ying Wu, Yucheng Gu, Jianguang Luo, Lingyi Kong.  (2023)  Efficient discovery of potent α-glucosidase inhibitors from Paeoniae lactiflora using enzyme–MOF nanocomposites and competitive indicators.  Food & Function,  14  (1): (171-180). 
2. Yang Liu, Xue Zhou, Dan Zhou, Yongxing Jian, Jingfu Jia, Fahuan Ge.  (2022)  Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism.  MOLECULES,  27  (18): (5742). 
3. Yanfang Yu, Yuhuan Chen, Xuping Shi, Chuan Ye, Junwen Wang, Jinzhi Huang, Bing Zhang, Zeyuan Deng.  (2022)  Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response.  Food & Function,  13  (16): (8593-8604). 
4. Yanfang Yu, Hongyan Li, Bing Zhang, Junwen Wang, Xuping Shi, Jinzhi Huang, Jianyuan Yang, Yanfei Zhang, Zeyuan Deng.  (2018)  Nutritional and functional components of mulberry leaves from different varieties: Evaluation of their potential as food materials.  INTERNATIONAL JOURNAL OF FOOD PROPERTIES,     

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