This is a demo store. No orders will be fulfilled.

 
Call +1 (833) 552-7181 or Contact us
Toggle Nav
My Cart
Search
Advanced Search
Menu
Account
Settings
྾
main product photo

1-(1-Naphthyl)piperazine - 98%, high purity , CAS No.57536-86-4, Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Antagonist of 5-ht 1e receptor;Antagonist of 5-HT 1F receptor;Antagonist of 5-HT 2B receptor;Agonist of 5-HT 6 receptor;Agonist of 5-HT 7 receptor

COA COA
  • Cas Number:  57536-86-4
  • Molecular Weight:  212.29
  • PubChem CID: 1342
In stock
Item Number
N335877
Grouped product items
SKU Size
Availability
 Price Qty
N335877-250mg
250mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$129.90
N335877-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$321.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

a mixed agonist/antagonist of the serotonin receptors

View related series
5-HT1A receptor Agonist (62) 5-HT1B receptor Agonist (45) 5-HT1D receptor Agonist (45) 5-ht1e receptor Antagonist (9) 5-HT1F receptor Antagonist (6) 5-HT2B receptor Antagonist (46) 5-HT6 receptor Agonist (27) 5-HT7 receptor Agonist (26)

Basic Description

Synonyms AKOS003591178 | N-(1-naphthyl) piperazine | CCG-205255 | DTXSID30973071 | Biomol-NT_000100 | Lopac-S-003 | N-(1- naphthyl)piperazine | SCHEMBL240244 | L001113 | 1-naphthalen-1-yl-piperazine, AldrichCPR | PDSP1_000930 | 1-(naphthalen-1-yl)piperazine | NCGC
Specifications & Purity Moligand™, ≥98%
Storage Temp Store at 2-8°C,Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST, ANTAGONIST
Mechanism of action Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Antagonist of 5-ht 1e receptor;Antagonist of 5-HT 1F receptor;Antagonist of 5-HT 2B receptor;Agonist of 5-HT 6 receptor;Agonist of 5-HT 7 receptor
Product Description

Product description：

1-(1-Naphthyl)piperazine is the hydrochloride salt preparation of 1-(1-Naphthyl)piperazine, a small molecule modulator of the 5-HT (serotonin) receptors with mixed activity. 1-(1-Naphthyl)piperazine demonstrates agonist activity at the 5-HT|1A|receptor and antagonist activity at the 5-HT|2A/2C|receptor. Blockade of the peripheral vascular pressor response to 5-HT and attenuation of the stimulus properties of 2,5-dimethoxy-4-methyl-amphetamine, both associated with the 5-HT2 receptor, are correlated to the 5-HT2 antagonism produced by 1-(1-Naphthyl)piperazine. The agonism of 5-HT|1A|produced by 1-(1-Naphthyl)piperazine is correlated to a reduction in 5-HT turnover and an increase in serum corticosterone. 1-(1-Naphthyl)piperazine is an inhibitor of SR-2A and an activator of SR-1A.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazinanes
Subclass Piperazines
Intermediate Tree Nodes Not available
Direct Parent N-arylpiperazines
Alternative Parents Naphthalenes  Dialkylarylamines  Dialkylamines  Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents N-arylpiperazine - Naphthalene - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Benzenoid - Tertiary amine - Azacycle - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as n-arylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an aryl group.
External Descriptors Not available

Product Properties

pKa pKₐ: 8.90 (Predicted)

Associated Targets(Human)

HTR1B Tclin 5-hydroxytryptamine receptor 1B (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR5A Tchem 5-hydroxytryptamine receptor 5A (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR2A Tclin 5-hydroxytryptamine receptor 2A (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR1E Tchem 5-hydroxytryptamine receptor 1E (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR7 Tclin 5-hydroxytryptamine receptor 7 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR1D Tclin 5-hydroxytryptamine receptor 1D (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR1F Tclin 5-hydroxytryptamine receptor 1F (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR1A Tclin 5-hydroxytryptamine receptor 1A (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR6 Tchem 5-hydroxytryptamine receptor 6 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR2B Tclin 5-hydroxytryptamine receptor 2B (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1D Tclin Serotonin 1d (5-HT1d) receptor (2897 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR5A Tchem Serotonin 5a (5-HT5a) receptor (1433 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR6 Tchem Serotonin 6 (5-HT6) receptor (9749 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCF1 Tbio Neutrophil cytosol factor 1 (245 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SHMT2 Tchem Serine hydroxymethyltransferase, mitochondrial (242 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Htr7 Serotonin 7 (5-HT7) receptor (19 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Htr2b Serotonin 2 (5-HT2) receptor (2078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Adra1b Adrenergic receptor alpha (950 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Htr3a Serotonin 3 (5-HT3) receptor (1834 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Htr1b Serotonin 1 (5-HT1) receptor (408 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 1-naphthalen-1-ylpiperazine
INCHI InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
InChIKey VNICFCQJUVFULD-UHFFFAOYSA-N
Smiles C1CN(CCN1)C2=CC=CC3=CC=CC=C32
Isomeric SMILES C1CN(CCN1)C2=CC=CC3=CC=CC=C32
WGK Germany 3
Alternate CAS 104113-71-5
Molecular Weight 212.29
Reaxy-Rn 176550
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=176550&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Soluble in water (25 mg/ml), and ethanol (slightly soluble).
Sensitivity Light & Moisture sensitive
Boil Point(°C) 391.9° C
Melt Point(°C) 318° C
Molecular Weight 212.290 g/mol
XLogP3 2.600
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 1
Exact Mass 212.131 Da
Monoisotopic Mass 212.131 Da
Topological Polar Surface Area 15.300 Ų
Heavy Atom Count 16
Formal Charge 0
Complexity 223.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.