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zurletrectinib , CAS No.2403703-30-8, Inhibitor of neurotrophic receptor tyrosine kinase 1

COA

Grade & Purity:

Moligand™

Cas Number: 2403703-30-8
PubChem CID: 156371488

In stock

Item Number

Z614990

Grouped product items
SKU	Size	Availability	Price	Qty
Z614990-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
Z614990-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,290.90

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neurotrophic receptor tyrosine kinase 1 Inhibitor (24) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms	10H-5,7-Ethenopyrazolo[4,3-g]pyrido[3,2-m]pyrrolo[1,2-k][1,4,6,9,11]oxatetraazacyclotetradecin-11(12H)-one, 2,18-difluoro-1,2,3,13,14,19b-hexahydro-14-methyl-,(2S,14S,19bR)- \| zurletrectinib [INN] \| Zurletrectinib \| GTPL12389 \| Zurletrectinib [USAN] \| 240
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of neurotrophic receptor tyrosine kinase 1

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyrazolopyrimidines
    - Subclass Pyrazolo[1,5-a]pyrimidines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyrazolopyrimidines
Subclass	Pyrazolo[1,5-a]pyrimidines
Intermediate Tree Nodes	Not available
Direct Parent	Pyrazolo[1,5-a]pyrimidines
Alternative Parents	Polyhalopyridines O-alkylpyrimidines Dialkylarylamines Methylpyridines Aralkylamines Alkyl aryl ethers 2-halopyridines Imidolactams Hydropyrimidines Pyrrolidines Pyrazoles Heteroaromatic compounds Organic carbonic acids and derivatives Vinyl fluorides Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Hydrazones Fluoroalkenes Carboximidamides Azacyclic compounds Amidines Organopnictogen compounds Organofluorides Organic oxides Hydrocarbon derivatives Alkyl fluorides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pyrazolo[1,5-a]pyrimidine - O-alkylpyrimidine - Polyhalopyridine - Dialkylarylamine - Tertiary aliphatic/aromatic amine - 2-halopyridine - Methylpyridine - Aralkylamine - Alkyl aryl ether - Imidolactam - Pyrimidine - Pyridine - 1,2-dihydropyrimidine - Hydropyrimidine - Heteroaromatic compound - Pyrrolidine - Pyrazole - Azole - Tertiary amine - Carbonic acid derivative - Oxacycle - Azacycle - Fluoroalkene - Haloalkene - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Vinyl halide - Vinyl fluoride - Hydrazone - Ether - Amidine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as pyrazolo[1,5-a]pyrimidines. These are aromatic heterocyclic compounds containing a pyrazolo[3,4-d]pyrimidine ring system, which consists of a pyrazole ring fused to and sharing exactly one nitrogen atom with a pyrimidine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

NTRK1 Tclin High affinity nerve growth factor receptor (0 Activities)

Discover Target: NTRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C19H19F2N7O2/c1-10-6-23-19(29)25-14-8-24-28-3-2-16(26-17(14)28)27-9-12(21)5-15(27)13-4-11(20)7-22-18(13)30-10/h2-4,7-8,10,12,15H,5-6,9H2,1H3,(H2,23,25,29)/t10-,12-,15+/m0/s1
InChIKey	OIBWCYRRWAMTRW-ITDIGPHOSA-N
Smiles	C[C@H]1CNC(=O)Nc2c3nc(ccn3nc2)N2C[C@H](C[C@@H]2c2c(O1)ncc(c2)F)F
Isomeric SMILES	C[C@H]1CNC(=O)NC2=C3N=C(C=CN3N=C2)N4C[C@H](C[C@@H]4C5=C(O1)N=CC(=C5)F)F
PubChem CID	156371488

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