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Zoledronic Acid - 10mM in Water, high purity , CAS No.118072-93-8, Farnesyl diphosphate synthase inhibitor
Highly potent bisphosphonate. FPP synthase inhibitor.
Basic Description
Synonyms
70HZ18PH24 | CAS-118072-93-8 | SR-05000001436 | (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid | D08689 | FT-0601384 | GTPL3177 | NCGC00159521-02 | s1314 | AB01273947-03 | 1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid | AB01
Specifications & Purity
Moligand™, 10mM in Water
Biochemical and Physiological Mechanisms
Highly potent bisphosphonate. FPP synthase inhibitor. Inhibits osteoclastogenesis (IC 50 = 15 nM). Inhibits ASM and FDPS. Activates PKC. Inhibits osteoclastic bone resorption, shows antihypocalcemic and antiangiogenic effects in vivo.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Farnesyl diphosphate synthase inhibitor
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organic acids and derivatives
Class
Organic phosphonic acids and derivatives
Subclass
Bisphosphonates
Intermediate Tree Nodes
Not available
Direct Parent
Bisphosphonates
Alternative Parents
N-substituted imidazoles Organic phosphonic acids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework
Aromatic heteromonocyclic compounds
Substituents
Bisphosphonate - N-substituted imidazole - Heteroaromatic compound - Organophosphonic acid - Imidazole - Azole - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
Description
This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
External Descriptors
imidazoles - 1,1-bis(phosphonic acid)
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Names and Identifiers
IUPAC Name
(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
INCHI
InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
InChIKey
XRASPMIURGNCCH-UHFFFAOYSA-N
Smiles
C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
Isomeric SMILES
C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
PubChem CID
68740
Molecular Weight
272.09
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Molecular Weight
272.090 g/mol
XLogP3
-4.300
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
8
Rotatable Bond Count
4
Exact Mass
271.996 Da
Monoisotopic Mass
271.996 Da
Topological Polar Surface Area
153.000 Ų
Heavy Atom Count
16
Formal Charge
0
Complexity
327.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Wanzhen Li, Yongqi Yang, Jun Wang, Ting Ge, Shuixia Wan, Lin Gui, Yugui Tao, Ping Song, Liangjun Yang, Fei Ge, Weiwei Zhang.
(2024)
Establishment of bone-targeted nano-platform and the study of its combination with 2-deoxy-d-glucose enhanced photodynamic therapy to inhibit bone metastasis. Journal of the Mechanical Behavior of Biomedical Materials,
150
(106306).
2.
Yao Duan, Chanyuan Jin, Yuwei Wu, Yan Chen, Minjuan Zhang, Jun Qian, Ting Shuai, Jian Li, Huimin Chen, Dan Li.
(2023)
CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF. TISSUE & CELL,
85
(102223).
3.
Ting Ge, Zhang Weiwei, Fei Ge, Longbao Zhu, Ping Song, Wanzheng Li, Lin Gui, Wan Dong, Yugui Tao, Kai Yang.
(2022)
A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis. Biomaterials Science,
10
(7):
(1831-1843).
4.
Xi Cui, Yizhu Shan, Jiaxuan Li, Meng Xiao, Yuan Xi, Jianying Ji, Engui Wang, Baokun Zhang, Lingling Xu, Mingzhu Zhang, Zhou Li, Yingzi Zhang.
(2024)
Bifunctional Piezo-Enhanced PLLA/ZA Coating Prevents Aseptic Loosening of Bone Implants. ADVANCED FUNCTIONAL MATERIALS,
(2403759).
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4 Citations