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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Z646532-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$420.90
|
|
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Z646532-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$670.90
|
|
|
Z646532-25mg
|
25mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,350.90
|
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| Specifications & Purity | ≥99% |
|---|---|
| Biochemical and Physiological Mechanisms | ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator ( uPA ) inhibitor as a potential treatment for multiple sclerosis. IC 50 s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. |
| Storage Temp | Protected from light,Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator ( uPA ) inhibitor as a potential treatment for multiple sclerosis. IC 50 s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. In Vivo ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T 1/2 =2.8 h) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| Smiles | CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC=C2)=C(F)C=C1F)C(O)=O.[H]Cl |
|---|---|
| Molecular Weight | 450.86 |
| Solubility | DMSO : 100 mg/mL (221.80 mM; Need ultrasonic) |
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