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ZK 200775 - ≥99%(HPLC), high purity , CAS No.161605-73-8

COA COA
In stock
Item Number
Z287426
Grouped product items
SKU Size
Availability
 Price Qty
Z287426-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$36.90
Z287426-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$86.90
Z287426-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$387.90
Z287426-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,239.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

Competitive non-NMDA iGluR antagonist

View related series
iGluR (34) Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320)

Basic Description

Synonyms GTPL7636 | NCGC00159553-01 | Tox21_111745_1 | ZK1 | CS-0138509 | NCGC00159553-02 | UNII-E3AP71EM0O | ZK 200775 | HMS3413G20 | HMS3677G20 | ZK200775 161605-73-8 | DB12393 | DTXSID7046093 | [7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]
Specifications & Purity Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [3H]-AMPA (Ki= 120 nM) and [3H]-CNQX (Ki= 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC50values range from 2.5 to
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Product Description

Product description

Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazanaphthalenes
Subclass Benzodiazines
Intermediate Tree Nodes Not available
Direct Parent Quinoxalines
Alternative Parents Dialkylarylamines  Benzenoids  Pyrazines  Morpholines  Organic phosphonic acids  Heteroaromatic compounds  Lactams  Azacyclic compounds  Dialkyl ethers  Oxacyclic compounds  Organofluorides  Organic oxides  Alkyl fluorides  Hydrocarbon derivatives  Organophosphorus compounds  Organopnictogen compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Quinoxaline - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Morpholine - Oxazinane - Pyrazine - Benzenoid - Heteroaromatic compound - Organophosphonic acid - Organophosphonic acid derivative - Tertiary amine - Lactam - Azacycle - Oxacycle - Dialkyl ether - Ether - Organic oxide - Organooxygen compound - Organonitrogen compound - Organofluoride - Organophosphorus compound - Alkyl halide - Organohalogen compound - Alkyl fluoride - Amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as quinoxalines. These are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring.
External Descriptors Not available

Associated Targets(Human)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Xenopus sp. (29 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gria2 Glutamate receptor ionotropic, AMPA (2103 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name [7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]methylphosphonic acid
INCHI InChI=1S/C14H15F3N3O6P/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25)
InChIKey WZMQMKNCWDCCMT-UHFFFAOYSA-N
Smiles C1COCCN1C2=CC3=C(C=C2C(F)(F)F)NC(=O)C(=O)N3CP(=O)(O)O
Isomeric SMILES C1COCCN1C2=CC3=C(C=C2C(F)(F)F)NC(=O)C(=O)N3CP(=O)(O)O
Alternate CAS 1255517-78-2
Molecular Weight 409.25

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 40.93, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 20.46, Max Conc. mM: 50
Molecular Weight 409.250 g/mol
XLogP3 -0.500
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 10
Rotatable Bond Count 3
Exact Mass 409.065 Da
Monoisotopic Mass 409.065 Da
Topological Polar Surface Area 119.000 Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 650.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. Fanapanel hydrate
    Fanapanel hydrate
    • ≥99%

    Starting at $168.90

  2. no_selection
    Fanapanel hydrate
    • 10mM in DMSO

    Starting at $185.90

Solution Calculators

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