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zidesamtinib , CAS No.Z614962, Inhibitor of c-ros oncogene 1; receptor tyrosine kinase;Inhibitor of neurotrophic receptor tyrosine kinase 1

COA

Grade & Purity:

Moligand™

PubChem CID: 166560233

In stock

Item Number

Z614962

Grouped product items
SKU	Size	Availability	Price	Qty
Z614962-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
Z614962-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,390.90

View related series

c-ros oncogene 1，receptor tyrosine kinase Inhibitor (5) neurotrophic receptor tyrosine kinase 1 Inhibitor (24)

Basic Description

Synonyms	Example 5 [US383715659] \| SCHEMBL24007115 \| EX-A8016 \| NVL520 \| NVL-520 \| 2739829-00-4 \| MX5KQV5XHC \| Zidesamtinib \| zidesamtinib [INN] \| GTPL12392
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of c-ros oncogene 1; receptor tyrosine kinase;Inhibitor of neurotrophic receptor tyrosine kinase 1

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazines
    - Subclass Pyrimidines and pyrimidine derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazines
Subclass	Pyrimidines and pyrimidine derivatives
Intermediate Tree Nodes	Not available
Direct Parent	O-alkylpyrimidines
Alternative Parents	Polyhalopyridines Methylpyridines Alkyl aryl ethers 2-halopyridines Imidolactams Benzenoids Triazoles Heteroaromatic compounds Vinyl fluorides Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Hydrazones Fluoroalkenes Azacyclic compounds Aldimines Organopnictogen compounds Organofluorides Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	O-alkylpyrimidine - Polyhalopyridine - 2-halopyridine - Methylpyridine - Alkyl aryl ether - Imidolactam - Benzenoid - Pyridine - Heteroaromatic compound - 1,2,3-triazole - Azole - Oxacycle - Azacycle - Fluoroalkene - Haloalkene - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Vinyl halide - Vinyl fluoride - Hydrazone - Ether - Aldimine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Primary aliphatic amine - Imine - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as o-alkylpyrimidines. These are compounds containing a pyrimidine , which is O-alkylated at one or more ring positions.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ROS1 Tclin Proto-oncogene tyrosine-protein kinase ROS (0 Activities)

Discover Target: ROS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor (0 Activities)

Discover Target: NTRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9-17(16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25)/t12-/m1/s1
InChIKey	DTWUUAFTYSMNQX-GFCCVEGCSA-N
Smiles	CCN1N=CC2=C1C3=CC(O[C@H](C)C4=CC(F)=CC=C4C5=NN(C)N=C5C2)=C(N)N=C3
Isomeric SMILES	CCN1C2=C(CC3=NN(N=C3C4=C(C=C(C=C4)F)[C@H](OC5=C(N=CC2=C5)N)C)C)C=N1
PubChem CID	166560233

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