Z-VDVAD-FMK is a special inhibitor of caspase-2 . Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis.
Storage Temp
Desiccated,Store at -80°C
Shipped In
Ice chest + Ice pads
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Product Description
Z-VDVAD-FMK is a special inhibitor of caspase-2 . Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis
In Vitro
Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100 μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death. Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells. Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: The human T-cell leukemia Jurkat (Clone E6.1, ATCC TIB-152) Concentration: 100 μM Incubation Time: 22 hours Result: Prevented Doxorubicin (1 μM)-induced nuclear apoptosis, but not cell death.
This compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
