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Yoda 1 - 98%, high purity , CAS No.448947-81-7, Activator of Piezo1

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Yoda 1 - 98%, high purity , CAS No.448947-81-7, Activator of Piezo1

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 448947-81-7
Molecular Weight: 355.27
PubChem CID: 2746822
PubChem SID: 504761405

In stock

Item Number

Y287590

Grouped product items
SKU	Size	Availability	Price
Y287590-5mg	5mg	3	$26.90
Y287590-10mg	10mg	3	$39.90
Y287590-25mg	25mg	2	$70.90
Y287590-50mg	50mg	2	$109.90
Y287590-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$329.90

Piezo1 channel activator

View related series

Akt (180) ERK (132) Ion channel (2197) MAPK/ERK Pathway (546) Membrane Transporter/Ion Channel (1822) PI3K/Akt/mTOR (765) Piezo Channel (3) Piezo1 Activator (3) Potassium Channel (253) Stem Cell/Wnt (1019)

Basic Description

Synonyms	GTPL9817 \| s6678 \| UNII-TW6GF9RW6S \| 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine \| 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine \| 2-[5-(2,6-Dichloro-benzylsulfanyl)-[1,3,4]thiadiazol-2-yl]-pyrazine \| N
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Piezo1 channel activator. Slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure, in HEK cells expressing Piezo1 channels.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of Piezo1

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Halobenzenes
      - Level5 Chlorobenzenes
        Level6 Dichlorobenzenes

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Halobenzenes
Intermediate Tree Nodes	Chlorobenzenes
Direct Parent	Dichlorobenzenes
Alternative Parents	Alkylarylthioethers Pyrazines Aryl chlorides Thiadiazoles Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Aryl thioether - 1,3-dichlorobenzene - Alkylarylthioether - Aryl chloride - Aryl halide - Pyrazine - Azole - Heteroaromatic compound - Thiadiazole - Azacycle - Organoheterocyclic compound - Sulfenyl compound - Thioether - Organonitrogen compound - Organochloride - Organohalogen compound - Organosulfur compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PIEZO1 Tchem Piezo-type mechanosensitive ion channel component 1 (2 Activities)

Discover Target: PIEZO1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504761405
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504761405
IUPAC Name	2-[(2,6-dichlorophenyl)methylsulfanyl]-5-pyrazin-2-yl-1,3,4-thiadiazole
INCHI	InChI=1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
InChIKey	BQNXBSYSQXSXPT-UHFFFAOYSA-N
Smiles	C1=CC(=C(C(=C1)Cl)CSC2=NN=C(S2)C3=NC=CN=C3)Cl
Isomeric SMILES	C1=CC(=C(C(=C1)Cl)CSC2=NN=C(S2)C3=NC=CN=C3)Cl
PubChem CID	2746822
Molecular Weight	355.27

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
I2203457	Certificate of Analysis	Jun 09, 2025	Y287590
I2205513	Certificate of Analysis	Jun 09, 2025	Y287590
I2203459	Certificate of Analysis	Jun 09, 2025	Y287590
I2203460	Certificate of Analysis	Jun 09, 2025	Y287590
D2511638	Certificate of Analysis	Mar 29, 2025	Y287590
D2511635	Certificate of Analysis	Mar 29, 2025	Y287590
D2511636	Certificate of Analysis	Mar 29, 2025	Y287590
D2511637	Certificate of Analysis	Mar 29, 2025	Y287590
D2511639	Certificate of Analysis	Mar 29, 2025	Y287590
L2405055	Certificate of Analysis	Jun 20, 2022	Y287590

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 7.11, Max Conc. mM: 20
Molecular Weight	355.300 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	353.957 Da
Monoisotopic Mass	353.957 Da
Topological Polar Surface Area	105.000 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	329.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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