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Metabolic Enzyme/Protease
Acyltransferase
YM 750 - ≥98%(HPLC), high purity , CAS No.138046-43-2

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YM 750 - ≥98%(HPLC), high purity , CAS No.138046-43-2

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 138046-43-2
Molecular Weight: 452.63
PubChem CID: 9911716

In stock

Item Number

Y287168

Grouped product items
SKU	Size	Availability	Price
Y287168-1mg	1mg	3	$48.90
Y287168-5mg	5mg	3	$102.90
Y287168-10mg	10mg	3	$167.90
Y287168-25mg	25mg	3	$335.90
Y287168-50mg	50mg	2	$543.90
Y287168-100mg	100mg	2	$939.90

ACAT inhibitor

View related series

Acyltransferase (66) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	HY-107396 \| NCGC00371091-01 \| Urea, N-cycloheptyl-N-(9H-fluoren-2-ylmethyl)-N'-(2,4,6-trimethylphenyl)- \| MS-28238 \| J-007090 \| YM750 \| YM-750 \| YM 750 \| CS-0028367 \| AKOS024457396 \| SCHEMBL4106190 \| 1-cycloheptyl-1-(9H-fluoren-2-ylmethyl)-3-(2,4,6-trimet
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50= 0.18μM). Exhibits hypocholesterolaemic and antiatherosclerotic activityin vivo.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Fluorenes

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Fluorenes
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Fluorenes
Alternative Parents	N-phenylureas Ureas Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	Fluorene - N-phenylurea - Monocyclic benzene moiety - Urea - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aromatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-cycloheptyl-1-(9H-fluoren-2-ylmethyl)-3-(2,4,6-trimethylphenyl)urea
INCHI	InChI=1S/C31H36N2O/c1-21-16-22(2)30(23(3)17-21)32-31(34)33(27-11-6-4-5-7-12-27)20-24-14-15-29-26(18-24)19-25-10-8-9-13-28(25)29/h8-10,13-18,27H,4-7,11-12,19-20H2,1-3H3,(H,32,34)
InChIKey	FMLJREWZCZHGGW-UHFFFAOYSA-N
Smiles	CC1=CC(=C(C(=C1)C)NC(=O)N(CC2=CC3=C(C=C2)C4=CC=CC=C4C3)C5CCCCCC5)C
Isomeric SMILES	CC1=CC(=C(C(=C1)C)NC(=O)N(CC2=CC3=C(C=C2)C4=CC=CC=C4C3)C5CCCCCC5)C
PubChem CID	9911716
Molecular Weight	452.63

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C2317358	Certificate of Analysis	Jan 16, 2023	Y287168
C2317378	Certificate of Analysis	Jan 16, 2023	Y287168
C2317375	Certificate of Analysis	Jan 16, 2023	Y287168
C2317364	Certificate of Analysis	Jan 16, 2023	Y287168
C2317363	Certificate of Analysis	Jan 16, 2023	Y287168
C2317379	Certificate of Analysis	Jan 16, 2023	Y287168

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 45.26, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 4.53, Max Conc. mM: 10
Molecular Weight	452.600 g/mol
XLogP3	7.700
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	4
Exact Mass	452.283 Da
Monoisotopic Mass	452.283 Da
Topological Polar Surface Area	32.299 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	658.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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