Skip to the beginning of the images gallery

YF-2 - 98%, high purity , CAS No.1311423-89-8

COA

Grade & Purity:

≥98%

Cas Number: 1311423-89-8
Molecular Weight: 430.85
PubChem CID: 53230697
PubChem SID: 488201556

In stock

Item Number

Y412127

Grouped product items
SKU	Size	Availability	Price
Y412127-5mg	5mg	3	$147.90
Y412127-10mg	10mg	2	$236.90
Y412127-25mg	25mg	1	$494.90
Y412127-50mg	50mg	1	$840.90
Y412127-100mg	100mg	1	$1,345.90

Histone Acetyltransferase Activators

View related series

Epigenetics (1496) Histone Acetyltransferase (79) Histone Modification (1379)

Basic Description

Synonyms	BS-15116 \| YF2 \| YF-2 \| UNII-N5WK32GRK4 \| HY-16531 \| SCHEMBL9951429 \| EX-A3626 \| N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide \| N17041 \| AKOS037648660 \| YF 2;YF2 \| N5WK32GRK4 \| TZHLDFAKTWDTOW-UHFFFAOYSA-O \| YF 2 \| B
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	YF-2 is a highly selective, blood-brain-barrier permeable activator of histone acetyltransferase (HAT). In In vitro assays, YF-2 has activity versus CBP, PCAF, and GCN5 with EC50 of 2.75 μΜ, 29.04 μΜ and 49.3 μΜ, respectively. YF-2 also increases p300 act
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information YF-2 YF-2 is a highly selective, blood-brain-barrier permeable activator of histone acetyltransferase (HAT) . In In vitro assays, YF-2 has activity versus CBP, PCAF, and GCN5 with EC50 of 2.75 μΜ, 29.04 μΜ and 49.3 μΜ, respectively. YF-2 also increases p300 activity. Targets HAT ; p300 ; CBP (Cell-based assay); PCAF (Cell-based assay); GCN5 (Cell-based assay) ; 2.75 μM(EC50); 29.04 μM(EC50); 49.3 μM(EC50)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Anilides
      - Level5 Aromatic anilides
        Level6 Benzanilides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Anilides
Intermediate Tree Nodes	Aromatic anilides
Direct Parent	Benzanilides
Alternative Parents	Trifluoromethylbenzenes Benzamides Benzoyl derivatives Phenol ethers Phenoxy compounds Chlorobenzenes Alkyl aryl ethers Aryl chlorides Trialkylamines Amino acids and derivatives Secondary carboxylic acid amides Organopnictogen compounds Organofluorides Organochlorides Organic oxides Hydrocarbon derivatives Alkyl fluorides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Benzanilide - Trifluoromethylbenzene - Benzamide - Benzoic acid or derivatives - Phenoxy compound - Benzoyl - Phenol ether - Alkyl aryl ether - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Amino acid or derivatives - Tertiary aliphatic amine - Carboxamide group - Tertiary amine - Secondary carboxylic acid amide - Ether - Carboxylic acid derivative - Organic nitrogen compound - Amine - Alkyl halide - Alkyl fluoride - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organohalogen compound - Organochloride - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	4.676
HBD Count	1
Rotatable Bond	9

Names and Identifiers

Pubchem Sid	488201556
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201556
IUPAC Name	N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide
INCHI	InChI=1S/C20H22ClF3N2O3/c1-4-28-16-6-5-7-17(29-11-10-26(2)3)18(16)19(27)25-13-8-9-15(21)14(12-13)20(22,23)24/h5-9,12H,4,10-11H2,1-3H3,(H,25,27)
InChIKey	TZHLDFAKTWDTOW-UHFFFAOYSA-N
Smiles	CCOC1=C(C(=CC=C1)OCCN(C)C)C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F
Isomeric SMILES	CCOC1=C(C(=CC=C1)OCCN(C)C)C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F
PubChem CID	53230697
Molecular Weight	430.85

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
E2309233	Certificate of Analysis	Apr 03, 2023	Y412127
E2309192	Certificate of Analysis	Apr 03, 2023	Y412127
E2309191	Certificate of Analysis	Apr 03, 2023	Y412127
E2309193	Certificate of Analysis	Apr 03, 2023	Y412127
E2309242	Certificate of Analysis	Apr 03, 2023	Y412127
E2309733	Certificate of Analysis	Apr 03, 2023	Y412127
E2309195	Certificate of Analysis	Apr 03, 2023	Y412127
E2309194	Certificate of Analysis	Apr 03, 2023	Y412127
E2309235	Certificate of Analysis	Apr 03, 2023	Y412127
E2309203	Certificate of Analysis	Apr 03, 2023	Y412127

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 86 mg/mL (199.6 mM); Water: 86 mg/mL (199.6 mM); Ethanol: 86 mg/mL (199.6 mM);
DMSO(mg / mL) Max Solubility	86
DMSO(mM) Max Solubility	199.605431124521
Water(mg / mL) Max Solubility	86
Water(mM) Max Solubility	199.605431124521
Molecular Weight	430.800 g/mol
XLogP3	4.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	8
Exact Mass	430.127 Da
Monoisotopic Mass	430.127 Da
Topological Polar Surface Area	50.800 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	522.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration