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YC-001 - 99%, high purity , CAS No.748778-73-6

COA

Grade & Purity:

≥99%

Cas Number: 748778-73-6
Molecular Weight: 282.77
PubChem CID: 2377702

In stock

Item Number

Y649465

Grouped product items
SKU	Size	Availability	Price
Y649465-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$90.90
Y649465-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
Y649465-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
Y649465-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$480.90
Y649465-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$720.90

View related series

Endogenous Metabolite (959) Metabolic Enzyme/Protease (4860) Metabolite (5307)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	YC-001 is an inverse agonist and antagonist of rod opsin . YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	YC-001 is an inverse agonist and antagonist of rod opsin . YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration In Vitro YC-001 (0-100 µM) shows a potency activity of 8.7 µM and an efficacy at 150–310%. YC-001 (0.5, 1, 5, 10, 20, 40 µM) improves the glycosylation profile of P23H opsin mutant. YC-001 (0,-1.5 µM) reversibly binds rod opsin with EC 50 OF 0.98 µM. YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 µM) increases in cAMP level in a dose-dependent manner in NIH3T3 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: NIH3T3 cells Concentration: 0.5, 1, 5, 10, 20, 40 µM Incubation Time: Result: Improved the glycosylation profile of P23H opsin. In Vivo YC-001 (50, 200mg/kg; i.p.) protects Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration . YC-001 (200mg/kg; i.p.) enters mouse eyes after systemic administration but is not retained for prolonged periods . YC-001 (100 mg/kg, 200 mg/kg; i.p.; daily for 24 days) shows virtually no acute toxicity . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-week-old Abca4 −/−Rdh8−/− mice Dosage: 50, 200mg/kg Administration: I.P. Result: Protected Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration. Animal Model: C57BL/6 mouse Dosage: 200 mg/kg Administration: I.P. Result: Entered mouse eyes after systemic administration but is not retained for prolonged periods. Animal Model: C57BL/6 mice Dosage: 100 mg/kg, 200 mg/kg Administration: I.p.; daily, 24 days Result: Showed no acute toxicity. Form:Solid IC50& Target:rod opsin

Names and Identifiers

Smiles	C1C(=C(C(=O)O1)C2=CC=CS2)C3=CC=C(S3)Cl
Isomeric SMILES	C1C(=C(C(=O)O1)C2=CC=CS2)C3=CC=C(S3)Cl
PubChem CID	2377702
Molecular Weight	282.77

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (353.64 mM; Need ultrasonic)
Molecular Weight	282.800 g/mol
XLogP3	3.400
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	281.958 Da
Monoisotopic Mass	281.958 Da
Topological Polar Surface Area	82.800 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	370.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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