This is a demo store. No orders will be fulfilled.

 
Call +1 (833) 552-7181 or Contact us
Toggle Nav
My Cart
Search
Advanced Search
Menu
Account
Settings
྾
main product photo

Xanthohumol - ≥97.0%(HPLC), high purity , CAS No.6754-58-1

5 Citations COA COA
    Grade & Purity:
  • ≥97%(HPLC)
In stock
Item Number
X139169
Grouped product items
SKU Size
Availability
 Price Qty
X139169-5mg
5mg
2
$59.90
X139169-10mg
10mg
2
$89.90
X139169-25mg
25mg
2
$189.90
X139169-100mg
100mg
3
$599.90
X139169-250mg
250mg
3
$649.90
X139169-1g
1g
3
$1,799.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

p97 ATPase (VCP) inhibitor

View related series
Acyltransferase (66) Anti-infection (2803) Apoptosis (4276) CMV (33) COX (258) HSV (104) Immunology/Inflammation (1929) Influenza Virus (253) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860) Phenylpropanoids (153) Six membered carbocyclic compound (243) Virus (1811)

Basic Description

Synonyms MFCD00210576 | DTXSID00893171 | Xanthohumol, primary pharmaceutical reference standard | (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one | AKOS040762512 | 2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-
Specifications & Purity ≥97%(HPLC)
Biochemical and Physiological Mechanisms p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50= 50.3μM).
Storage Temp Store at 2-8°C,Protected from light,Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Linear 1,3-diarylpropanoids
Subclass Chalcones and dihydrochalcones
Intermediate Tree Nodes Not available
Direct Parent 3-prenylated chalcones
Alternative Parents 2'-Hydroxychalcones  Cinnamylphenols  Hydroxycinnamic acids and derivatives  Methoxyphenols  Styrenes  Resorcinols  Phenoxy compounds  Anisoles  Methoxybenzenes  Aryl ketones  Benzoyl derivatives  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Alkyl aryl ethers  Vinylogous acids  Acryloyl compounds  Enones  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents 3-prenylated chalcone - 2'-hydroxychalcone - Cinnamylphenol - Hydroxycinnamic acid or derivatives - Methoxyphenol - Phenoxy compound - Phenol ether - Resorcinol - Styrene - Aryl ketone - Anisole - Methoxybenzene - Benzoyl - Phenol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Benzenoid - Monocyclic benzene moiety - Acryloyl-group - Vinylogous acid - Enone - Alpha,beta-unsaturated ketone - Ketone - Ether - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as 3-prenylated chalcones. These are chalcones featuring a C5-isoprenoid unit at the 3-position.
External Descriptors Chalcones and dihydrochalcones

Associated Targets(Human)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CASP3 Tchem Caspase-3 (3632 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDPK1 Tchem 3-phosphoinositide dependent protein kinase-1 (3758 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPK9 Tchem c-Jun N-terminal kinase 2 (4655 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PRKCA Tchem Protein kinase C alpha (5923 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PRKCQ Tchem Protein kinase C theta (3319 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BGC-823 (3035 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Caco-2 (12174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DU-145 (51482 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H1975 (4994 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SGC-7901 (2773 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T98G (1524 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-87 MG (3946 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HUVEC (11049 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ishikawa (877 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LNCaP (8286 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SETD7 Tchem Histone-lysine N-methyltransferase SETD7 (390 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DGAT1 Tclin Diacylglycerol O-acyltransferase 1 (1719 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver (3974 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPK3 Tchem Mitogen-activated protein kinase; ERK1/ERK2 (651 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPK13 Tchem MAP kinase p38 (1586 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NFKB2 Tchem Nuclear factor NF-kappa-B complex (2307 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LY96 Tchem Lymphocyte antigen 96 (117 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LNCaP C4-2 (165 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Ttr Transthyretin (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGES Prostaglandin E synthase (10 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEF (1005 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BV-2 (3710 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRXR Thioredoxin reductase (20 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nqo1 NAD(P)H dehydrogenase [quinone] 1 (1058 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Akt1 RAC-alpha serine/threonine-protein kinase (147 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bcl2l1 Bcl-2-like protein 1 (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504759669
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504759669
IUPAC Name (E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
INCHI InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
InChIKey ORXQGKIUCDPEAJ-YRNVUSSQSA-N
Smiles CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)C=CC2=CC=C(C=C2)O)O)C
Isomeric SMILES CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)/C=C/C2=CC=C(C=C2)O)O)C
WGK Germany 3
PubChem CID 639665
Molecular Weight 354.4

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number Certificate Type Date Item
G2325043 Certificate of Analysis May 07, 2025 X139169
F2307290 Certificate of Analysis Mar 04, 2025 X139169
F2418189 Certificate of Analysis Jun 06, 2024 X139169
F2418190 Certificate of Analysis Jun 06, 2024 X139169
F2418191 Certificate of Analysis Jun 06, 2024 X139169
F2418192 Certificate of Analysis Jun 06, 2024 X139169
F2418193 Certificate of Analysis Jun 06, 2024 X139169
G2214478 Certificate of Analysis Apr 07, 2024 X139169
G2214255 Certificate of Analysis Apr 07, 2024 X139169
G2214477 Certificate of Analysis Apr 07, 2024 X139169
B2210169 Certificate of Analysis Nov 16, 2023 X139169
H1901149 Certificate of Analysis Mar 17, 2023 X139169
K1801022 Certificate of Analysis Jul 11, 2022 X139169
G2214253 Certificate of Analysis Jun 09, 2022 X139169

Show more⌵

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 35.44, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 35.44, Max Conc. mM: 100
Sensitivity Light Sensitive,Air Sensitive,Heat Sensitive
Melt Point(°C) 159 °C
Molecular Weight 354.400 g/mol
XLogP3 5.100
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 6
Exact Mass 354.147 Da
Monoisotopic Mass 354.147 Da
Topological Polar Surface Area 87.000 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 514.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 1
Covalently-Bonded Unit Count 1

Alternative Products

  1. Xanthohumol
    Xanthohumol
    • 10mM in DMSO

    Starting at $69.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Fa-Li Zhang, Liu Yang, Wei-Hao He, Ling-Jun Xie, Fei Yang, Ying-Hui Wang, Ai-Guo Huang.  (2023)  In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection.  JOURNAL OF FISH DISEASES,  46  (9): (977-986). 
2. Wei Liu, Xiao Chen, Chen Yang, Zequn Lin, Xinfeng Huang, Zhen Zhang, Jianjun Liu.  (2025)  Preventive effects of xanthohumol in APP/PS1 mice based on multi-omics atlas.  BRAIN RESEARCH BULLETIN,  224  (111316). 
3. Liu Wei, Chen Xiao, Zhao Jing, Yang Chen, Huang Guanqin, Zhang Zhen, Liu Jianjun.  (2024)  Protective signature of xanthohumol on cognitive function of APP/PS1 mice: a urine metabolomics approach by age.  Frontiers in Pharmacology,  15   
4. Yan Gao, Zilin Song, Wenxin Gan, Xue Zou, Yaning Bai, Xiuli Zhao, Dawei Chen, Mingxi Qiao.  (2025)  Selective and iron-independent ferroptosis in cancer cells induced by manipulation of mitochondrial fatty acid oxidation.  BIOMATERIALS,  320  (123259). 
5. Han Ning, Li Jie, Li Yangyang, Zhao Feiei, Wang Jun, Ye Peiyu, Zeng Zhenling.  (2025)  Xanthohumol ameliorates dextran sodium sulfate-induced colitis in mice by inhibiting of NF-κB signaling pathways and modulating intestinal microbiota.  EUROPEAN JOURNAL OF NUTRITION,  64  (1): (1-13). 

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.