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WZ8040 - ≥98%, high purity , CAS No.1214265-57-2

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
W126471
Grouped product items
SKU Size
Availability
 Price Qty
W126471-1mg
1mg
3
$27.90
W126471-5mg
5mg
3
$93.90
W126471-10mg
10mg
2
$139.90
W126471-25mg
25mg
1
$239.90
W126471-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$359.90
W126471-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$539.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
EGFR (254) EGFR inhibitor (2) JAK/STAT Signaling (507) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms CS-0171 | AKOS027276489 | EX-A4023 | SW219395-1 | W-108455 | FT-0728045 | WZ8040 | WZ-8040 | F82898 | AC-32056 | CCG-269557 | SCHEMBL93523 | SMR004703030 | N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide |
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms WZ8040 is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ8040 treatment potently inhibits the growth of HCC827 (EGFR Del E746_A
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).
A potent inhibitor of EGFR T790M

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazinanes
Subclass Piperazines
Intermediate Tree Nodes Not available
Direct Parent Phenylpiperazines
Alternative Parents N-arylpiperazines  Diarylthioethers  Anilides  Thiophenol ethers  Aniline and substituted anilines  Dialkylarylamines  N-arylamides  Aminopyrimidines and derivatives  N-methylpiperazines  Halopyrimidines  Aryl chlorides  Acrylic acids and derivatives  Heteroaromatic compounds  Secondary carboxylic acid amides  Trialkylamines  Amino acids and derivatives  Azacyclic compounds  Secondary amines  Sulfenyl compounds  Organic oxides  Organochlorides  Carbonyl compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Phenylpiperazine - N-arylpiperazine - Diarylthioether - Anilide - Aryl thioether - Thiophenol ether - N-arylamide - Dialkylarylamine - Aniline or substituted anilines - Aminopyrimidine - Halopyrimidine - N-methylpiperazine - N-alkylpiperazine - Monocyclic benzene moiety - Benzenoid - Aryl halide - Aryl chloride - Pyrimidine - Heteroaromatic compound - Acrylic acid or derivatives - Amino acid or derivatives - Carboxamide group - Tertiary aliphatic amine - Secondary carboxylic acid amide - Tertiary amine - Carboxylic acid derivative - Secondary amine - Azacycle - Sulfenyl compound - Thioether - Organic oxide - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Carbonyl group - Organosulfur compound - Organic nitrogen compound - Organic oxygen compound - Amine - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
External Descriptors Not available

Associated Targets(Human)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H1975 (4994 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-9 (1037 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BaF3 (4657 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide
INCHI InChI=1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)
InChIKey KIISCIGBPUVZBF-UHFFFAOYSA-N
Smiles CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl
Isomeric SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl
PubChem CID 44607531
Molecular Weight 481.02

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
F2426172 Certificate of Analysis Mar 08, 2024 W126471
F2426173 Certificate of Analysis Mar 08, 2024 W126471
F2426169 Certificate of Analysis Mar 08, 2024 W126471
F2426170 Certificate of Analysis Mar 08, 2024 W126471
F2426174 Certificate of Analysis Mar 08, 2024 W126471
F2426175 Certificate of Analysis Mar 08, 2024 W126471
F2426177 Certificate of Analysis Mar 08, 2024 W126471
F2426171 Certificate of Analysis Mar 08, 2024 W126471
F2426176 Certificate of Analysis Mar 08, 2024 W126471
F2426178 Certificate of Analysis Mar 08, 2024 W126471

Chemical and Physical Properties

Solubility DMSO ≥93mg/mL Water <1.2mg/mL Ethanol ≥2.8mg/mL
Molecular Weight 481.000 g/mol
XLogP3 4.800
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 7
Exact Mass 480.15 Da
Monoisotopic Mass 480.15 Da
Topological Polar Surface Area 98.700 Ų
Heavy Atom Count 33
Formal Charge 0
Complexity 640.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. no_selection
    WZ8040
    • 10mM in DMSO

    Starting at $784.90

Solution Calculators

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