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WZ 4003 - ≥98%, high purity , CAS No.1214265-58-3, Inhibitor of NUAK family kinase 1;Inhibitor of NUAK family; SNF1-like kinase; 2

1 Citations COA COA
In stock
Item Number
W275066
Grouped product items
SKU Size
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 Price Qty
W275066-5mg
5mg
3
$53.90
W275066-10mg
10mg
2
$86.90
W275066-25mg
25mg
2
$195.90
W275066-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$216.90
W275066-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$390.90
W275066-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$878.90
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Potent, selective NUAK kinase inhibitor

View related series
AMPK (95) DNA Methylation (216) Epigenetics (1496) NUAK family kinase 1 Inhibitor (8) NUAK family，SNF1-like kinase，2 Inhibitor (2) PI3K/Akt/mTOR (765)

Basic Description

Synonyms BCP09218 | CCG-264737 | WZ 4003 | C25H29ClN6O3 | WZ4003, >=98% (HPLC) | NCGC00386309-05 | s7317 | 1214265-58-3 | CS-3258 | N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)propionamide | Z335245084 | F20676 | NCGC
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Potent, selective NUAK kinase inhibitor (IC 50 values are 20 and 100 nM for NUAK1 and NUAK2, respectively). Impairs invasive potential of U2OS cells. Shows antiproliferative effects.
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of NUAK family kinase 1;Inhibitor of NUAK family; SNF1-like kinase; 2
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazinanes
Subclass Piperazines
Intermediate Tree Nodes Not available
Direct Parent Phenylpiperazines
Alternative Parents N-arylpiperazines  Diarylethers  Aminophenyl ethers  Anilides  Methoxyanilines  Phenoxy compounds  N-arylamides  Methoxybenzenes  Anisoles  Dialkylarylamines  Alkyl aryl ethers  Aminopyrimidines and derivatives  N-methylpiperazines  Halopyrimidines  Aryl chlorides  Heteroaromatic compounds  Trialkylamines  Secondary carboxylic acid amides  Amino acids and derivatives  Azacyclic compounds  Carbonyl compounds  Hydrocarbon derivatives  Organic oxides  Organochlorides  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents N-arylpiperazine - Phenylpiperazine - Diaryl ether - Anilide - Methoxyaniline - Aminophenyl ether - Methoxybenzene - N-arylamide - Aniline or substituted anilines - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Phenoxy compound - Phenol ether - Anisole - N-methylpiperazine - Halopyrimidine - Alkyl aryl ether - N-alkylpiperazine - Aminopyrimidine - Aryl chloride - Monocyclic benzene moiety - Benzenoid - Aryl halide - Pyrimidine - Heteroaromatic compound - Amino acid or derivatives - Tertiary aliphatic amine - Carboxamide group - Tertiary amine - Secondary carboxylic acid amide - Ether - Carboxylic acid derivative - Azacycle - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Amine - Hydrocarbon derivative - Organic oxide - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
External Descriptors Not available

Associated Targets(Human)

NUAK2 Tchem NUAK family SNF1-like kinase 2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
NUAK1 Tchem NUAK family SNF1-like kinase 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW480 (6023 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ULK2 Tchem Serine/threonine-protein kinase ULK2 (652 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NUAK1 Tchem NUAK family SNF1-like kinase 1 (1769 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
STK33 Tchem Serine/threonine-protein kinase 33 (769 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NUAK2 Tchem NUAK family SNF1-like kinase 2 (630 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK-293T (167025 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504772252
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772252
IUPAC Name N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide
INCHI InChI=1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30)
InChIKey SDGJBAUIGHSMRI-UHFFFAOYSA-N
Smiles CCC(=O)NC1=CC(=CC=C1)OC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)C)OC
Isomeric SMILES CCC(=O)NC1=CC(=CC=C1)OC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)C)OC
PubChem CID 72200024
Molecular Weight 497

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
I2413076 Certificate of Analysis Sep 20, 2024 W275066
B2209572 Certificate of Analysis Aug 10, 2023 W275066
B2209618 Certificate of Analysis Aug 10, 2023 W275066
B2209327 Certificate of Analysis Aug 10, 2023 W275066
B2209623 Certificate of Analysis Aug 10, 2023 W275066
B2209625 Certificate of Analysis Aug 10, 2023 W275066
B2209617 Certificate of Analysis Aug 10, 2023 W275066

Chemical and Physical Properties

Solubility Soluble in DMSO to 25 mM
Molecular Weight 497.000 g/mol
XLogP3 4.100
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 8
Exact Mass 496.199 Da
Monoisotopic Mass 496.199 Da
Topological Polar Surface Area 91.900 Ų
Heavy Atom Count 35
Formal Charge 0
Complexity 667.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Ruobing Wang, Dan Su, Yueze Liu, Hua Huang, Jiangdong Qiu, Zhe Cao, Gang Yang, Hao Chen, Wenhao Luo, Jinxin Tao, Guihu Weng, Taiping Zhang.  (2024)  The NF-κB/NUAK2 signaling axis regulates pancreatic cancer progression by targeting SMAD2/3.  iScience,  27  (109406). 

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