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WYE-125132 (WYE-132) - ≥98%, high purity , CAS No.1144068-46-1

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
W128041
Grouped product items
SKU Size
Availability
 Price Qty
W128041-5mg
5mg
3
$132.90
W128041-10mg
10mg
3
$230.90
W128041-25mg
25mg
2
$481.90
W128041-50mg
50mg
1
$768.90
W128041-100mg
100mg
1
$1,327.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Highly potent, ATP-competitive mTOR inhibitor

View related series
Apoptosis (4276) mTOR (145) PI3K/Akt/mTOR (765)

Basic Description

Synonyms EX-A2183 | WYE125132 | WYE-125132 | 3-(4-methoxyphenyl)-1-methyl-5-p-tolyl-1H-pyrazole | NCGC00346635-01 | Q27163233 | B0561 | CHEBI:91364 | Heveacrumb SMR 5L | SB19261 | Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms WYE-125132 is a potent, ATP-competitive inhibitor of recombinant mTOR kinase,with an IC50 of 0.19 nM. WYE-125132 shows an anti-proliferative activity against a variety of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116), in vitro. W
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.
A highly potent, ATP-competitive, and specific mTOR kinase inhibitor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass N-phenylureas
Intermediate Tree Nodes Not available
Direct Parent N-phenylureas
Alternative Parents Pyrazolo[3,4-d]pyrimidines  Dialkylarylamines  Aminopyrimidines and derivatives  Ketals  Azepanes  Morpholines  Imidolactams  Tetrahydrofurans  Pyrazoles  1,3-dioxolanes  Heteroaromatic compounds  Ureas  Oxacyclic compounds  Azacyclic compounds  Dialkyl ethers  Carbonyl compounds  Hydrocarbon derivatives  Organic oxides  Organopnictogen compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents N-phenylurea - Pyrazolopyrimidine - Pyrazolo[3,4-d]pyrimidine - Dialkylarylamine - Ketal - Azepane - Aminopyrimidine - Morpholine - Oxazinane - Imidolactam - Pyrimidine - Pyrazole - Azole - Heteroaromatic compound - Meta-dioxolane - Tetrahydrofuran - Carbonic acid derivative - Urea - Acetal - Dialkyl ether - Ether - Oxacycle - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Organic oxide - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as n-phenylureas. These are compounds containing a N-phenylurea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of a urea group.
External Descriptors Not available

Associated Targets(Human)

MTOR Tclin Serine/threonine-protein kinase mTOR (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-361 (612 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LNCaP (8286 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK-293T (167025 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

PIK3CA PI3-kinase p110-alpha subunit (51 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-3-methylurea
INCHI InChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)
InChIKey QLHHRYZMBGPBJG-UHFFFAOYSA-N
Smiles CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7
Isomeric SMILES CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7
PubChem CID 25260757
Molecular Weight 519.61

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
G2410690 Certificate of Analysis Mar 11, 2024 W128041
G2410561 Certificate of Analysis Mar 11, 2024 W128041
G2410562 Certificate of Analysis Mar 11, 2024 W128041
G2410563 Certificate of Analysis Mar 11, 2024 W128041
G2410564 Certificate of Analysis Mar 11, 2024 W128041
G2410565 Certificate of Analysis Mar 11, 2024 W128041
G2410566 Certificate of Analysis Mar 11, 2024 W128041
G2410576 Certificate of Analysis Mar 11, 2024 W128041
G2410688 Certificate of Analysis Mar 11, 2024 W128041
G2410689 Certificate of Analysis Mar 11, 2024 W128041

Chemical and Physical Properties

Solubility DMSO 104 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Molecular Weight 519.600 g/mol
XLogP3 2.200
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 4
Exact Mass 519.259 Da
Monoisotopic Mass 519.259 Da
Topological Polar Surface Area 116.000 Ų
Heavy Atom Count 38
Formal Charge 0
Complexity 829.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 2
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

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    WYE-125132 (WYE-132)
    • 10mM in DMSO

    Starting at $152.90

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