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WP1066 - ≥98%, high purity , CAS No.857064-38-1, Channel blocker of K v1.3;Inhibitor of signal transducer and activator of transcription 3

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 857064-38-1
Molecular Weight: 356.22
PubChem CID: 11210478
PubChem SID: 488197282

In stock

Item Number

W129459

Grouped product items
SKU	Size	Availability	Price
W129459-10mg	10mg	≥10	$90.90
W129459-50mg	50mg	≥10	$273.90
W129459-250mg	250mg	8	$1,233.90
W129459-1g	1g	6	$4,438.90

JAK/STAT3 inhibitor; AG 490 analog

View related series

Apoptosis (4276) Epigenetics (1496) Histone Modification (1379) JAK (149) JAK/STAT Signaling (507) Kv1.3 Channel blocker (13) Non-receptor Tyrosine Kinase (643) Protein Tyrosine Kinase/RTK (1314) signal transducer and activator of transcription 3 Inhibitor (8) STAT (139) Stem Cell/Wnt (1019)

Basic Description

Synonyms	AKOS016007983 \| AC-28413 \| GTPL7972 \| MFCD00445901 \| 63V8AIE65T \| BDBM50557738 \| MLS006010178 \| SCHEMBL1315831 \| STK888392 \| Q27089227 \| UNII-63V8AIE65T \| (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide \| 1-(3-phenyl-2-propenoyl)-piperid
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	WP1066 (WP10666) is a cell permeable AG 490 tyrphostin analog that effectively inhibits the STAT3 pathway. The inhibitor is a potent antitumor agent as displayed in the growth inhibition of malignant glioma cell and acute myelogenous leukemia cells. Stat3
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	CHANNEL BLOCKER, INHIBITOR
Mechanism of action	Channel blocker of K v1.3;Inhibitor of signal transducer and activator of transcription 3
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. A cell permeable inhibitor of Stat3 and JAK2 protein tyrosine kinase.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Halopyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Halopyridines
Intermediate Tree Nodes	Not available
Direct Parent	2-halopyridines
Alternative Parents	Benzene and substituted derivatives Aryl bromides Heteroaromatic compounds Secondary carboxylic acid amides Nitriles Azacyclic compounds Organobromides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-halopyridine - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Nitrile - Carbonitrile - Carboxylic acid derivative - Azacycle - Organic oxide - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Carbonyl group - Cyanide - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 2-halopyridines. These are organic compounds containing a pyridine ring substituted at the 2-position by a halogen atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

STAT3 Tchem Signal transducer and activator of transcription 3 (0 Activities)

Discover Target: STAT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNA3 Tclin Potassium voltage-gated channel subfamily A member 3 (0 Activities)

Discover Target: KCNA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STAT3 Tchem Signal transducer and activator of transcription 3 (3313 Activities)

Discover Target: STAT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U373 MG (658 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-87 MG (3946 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-266 (527 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK-293T (167025 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488197282
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488197282
IUPAC Name	(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
INCHI	InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
InChIKey	VFUAJMPDXIRPKO-LQELWAHVSA-N
Smiles	CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
Isomeric SMILES	C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
PubChem CID	11210478
Molecular Weight	356.22

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
E23121276	Certificate of Analysis	Feb 07, 2025	W129459
E23121302	Certificate of Analysis	Feb 07, 2025	W129459
E23121298	Certificate of Analysis	Feb 07, 2025	W129459
E23121304	Certificate of Analysis	Feb 07, 2025	W129459
E23121288	Certificate of Analysis	Feb 07, 2025	W129459
E23121300	Certificate of Analysis	Feb 07, 2025	W129459
J2130565	Certificate of Analysis	Aug 02, 2023	W129459
J2130566	Certificate of Analysis	Aug 02, 2023	W129459
G1530067	Certificate of Analysis	Feb 06, 2023	W129459
A2514055	Certificate of Analysis	Nov 08, 2022	W129459

Chemical and Physical Properties

Solubility	DMSO 72 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Molecular Weight	356.200 g/mol
XLogP3	3.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	355.032 Da
Monoisotopic Mass	355.032 Da
Topological Polar Surface Area	65.800 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	462.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Solution Calculators

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WP1066 - ≥98%, high purity , CAS No.857064-38-1, Channel blocker of K v1.3;Inhibitor of signal transducer and activator of transcription 3

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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