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WM-8014 - 99%, high purity , CAS No.2055397-18-5

COA

Grade & Purity:

≥99%

Cas Number: 2055397-18-5
Molecular Weight: 384.42
PubChem CID: 133053564
PubChem SID: 504773136

In stock

Item Number

W413571

Grouped product items
SKU	Size	Availability	Price
W413571-1mg	1mg	3	$36.90
W413571-5mg	5mg	3	$151.90
W413571-25mg	25mg	2	$467.90
W413571-100mg	100mg	2	$1,436.90

Histone Acetyltransferase Inhibitors

View related series

Epigenetics (1496) Histone Acetyltransferase (79) Histone Modification (1379)

Basic Description

Synonyms	[1,1'-Biphenyl]-3-carboxylic acid,4-fluoro-5-methyl-,2-(phenylsulfonyl)hydrazide
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information WM-8014 WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM. Targets KAT6A (Cell-free assay) 8 nM In vitro WM-8014 induces cell cycle arrest in embryonic day (E)14.5 mouse embryonic fibroblasts.Cells treated with WM-8014 failed to proliferate after ten days of treatment (IC50 2.4 μM). Higher doses of WM-8014 (up to 40 μM) did not accelerate growth arrest, which after eight days of treatment was irreversible. In vivo WM-8014 potentiates oncogene-induced senescence in a zebrafish model of hepatocellular carcinoma.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Biphenyls and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Biphenyls and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Biphenyls and derivatives
Alternative Parents	Benzenesulfonamides 2-halobenzoic acids and derivatives m-Toluamides Benzenesulfonyl compounds Benzoyl derivatives Fluorobenzenes Sulfonohydrazides Hydrazinosulfonyl compounds Aryl fluorides Vinylogous halides Carboxylic acids and derivatives Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Biphenyl - Halobenzoic acid or derivatives - 2-halobenzoic acid or derivatives - Benzenesulfonamide - Benzenesulfonyl group - M-toluamide - Toluamide - Benzoic acid or derivatives - Benzoyl - Toluene - Halobenzene - Fluorobenzene - Hydrazinosulfonyl compound - Sulfonohydrazide - Aryl halide - Aryl fluoride - Vinylogous halide - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KAT6B Tchem Histone acetyltransferase KAT6B (2 Activities)

Discover Target: KAT6B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT6A Tchem Histone acetyltransferase KAT6A (4 Activities)

Discover Target: KAT6A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT6A Tchem Histone acetyltransferase KAT6A (320 Activities)

Discover Target: KAT6A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504773136
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773136
IUPAC Name	N'-(benzenesulfonyl)-2-fluoro-3-methyl-5-phenylbenzohydrazide
INCHI	InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24)
InChIKey	PHHZKBMVRPULAW-UHFFFAOYSA-N
Smiles	CC1=CC(=CC(=C1F)C(=O)NNS(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES	CC1=CC(=CC(=C1F)C(=O)NNS(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3
PubChem CID	133053564
Molecular Weight	384.42

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
H2224334	Certificate of Analysis	Jun 09, 2025	W413571
H2224335	Certificate of Analysis	Jun 09, 2025	W413571
H2224337	Certificate of Analysis	Jun 09, 2025	W413571
H2224338	Certificate of Analysis	Jun 09, 2025	W413571

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 77 mg/mL (200.3 mM); Water: Insoluble; Ethanol: Insoluble;
Molecular Weight	384.400 g/mol
XLogP3	4.100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	384.094 Da
Monoisotopic Mass	384.094 Da
Topological Polar Surface Area	83.700 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	595.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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