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WAY-262611 - 99%, high purity , CAS No.1123231-07-1

COA

Grade & Purity:

≥99%

Cas Number: 1123231-07-1
Molecular Weight: 318.42
PubChem CID: 25199517
PubChem SID: 504770015

In stock

Item Number

W414491

Grouped product items
SKU	Size	Availability	Price
W414491-5mg	5mg	3	$71.90
W414491-10mg	10mg	3	$107.90
W414491-25mg	25mg	3	$243.90
W414491-50mg	50mg	3	$395.90
W414491-100mg	100mg	2	$712.90
W414491-250mg	250mg	2	$1,603.90

Wnt/beta-catenin Agonists

View related series

Stem Cell/Wnt (1019) β-catenin (56)

Basic Description

Synonyms	BML-WN1104-Piperidinemethanamine,1-[4-(2-naphthalenyl)-2-pyrimidinyl]- \| BML-WN110
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	WAY-262611 (BML-WN110, Compound 5) is a beta-catenin (β-Catenin) agonist that increases bone formation rate with EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also an inhibitor of dickkopf 1 (DKK1).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information WAY-262611 WAY-262611 (BML-WN110, Compound 5) is a beta-catenin (β-Catenin) agonist that increases bone formation rate with EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also an inhibitor of dickkopf 1 (DKK1) . Targets DKK1 ; β-Catenin (TCF-Luciferase assay) ; 0.63 μM(EC50) In vitro WAY-262611, the DKK1 inhibitor, blocks DKK1 and restores the GDF5 reduced MMP13 gene expression. In vivo WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Cell Research(from reference) Cell lines：Surplus human chondrocytes Concentrations：0.01 μM, 0.1 μM, 1 μM Incubation Time：21 days

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Naphthalenes

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Naphthalenes
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Naphthalenes
Alternative Parents	Dialkylarylamines Aminopyrimidines and derivatives Piperidines Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Naphthalene - Dialkylarylamine - Aminopyrimidine - Piperidine - Pyrimidine - Heteroaromatic compound - Organoheterocyclic compound - Azacycle - Hydrocarbon derivative - Organic nitrogen compound - Primary amine - Amine - Organonitrogen compound - Organopnictogen compound - Primary aliphatic amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

DKK1 Tchem Dickkopf-related protein 1 (1 Activities)

Discover Target: DKK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

Discover Target: GSK3B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsomes (16955 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DKK1 Tchem Dickkopf-related protein 1 (93 Activities)

Discover Target: DKK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770015
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770015
IUPAC Name	[1-(4-naphthalen-2-ylpyrimidin-2-yl)piperidin-4-yl]methanamine
INCHI	InChI=1S/C20H22N4/c21-14-15-8-11-24(12-9-15)20-22-10-7-19(23-20)18-6-5-16-3-1-2-4-17(16)13-18/h1-7,10,13,15H,8-9,11-12,14,21H2
InChIKey	QHLITPHIARVDJI-UHFFFAOYSA-N
Smiles	C1CN(CCC1CN)C2=NC=CC(=N2)C3=CC4=CC=CC=C4C=C3
Isomeric SMILES	C1CN(CCC1CN)C2=NC=CC(=N2)C3=CC4=CC=CC=C4C=C3
PubChem CID	25199517
Molecular Weight	318.42

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C2306207	Certificate of Analysis	Nov 07, 2022	W414491
C2306204	Certificate of Analysis	Nov 07, 2022	W414491
C2306199	Certificate of Analysis	Nov 07, 2022	W414491
C2306210	Certificate of Analysis	Nov 07, 2022	W414491
C2306197	Certificate of Analysis	Nov 07, 2022	W414491
C2303195	Certificate of Analysis	Nov 07, 2022	W414491

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 64 mg/mL (200.99 mM); Water: 10 mg/mL (31.4 mM); Ethanol: 10 mg/mL (31.4 mM);
Molecular Weight	318.400 g/mol
XLogP3	3.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	318.184 Da
Monoisotopic Mass	318.184 Da
Topological Polar Surface Area	55.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	393.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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WAY-262611 - 99%, high purity , CAS No.1123231-07-1

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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