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Vorasidenib (AG-881) - 98%, high purity , IDH1/IDH2 inhibitor, CAS No.1644545-52-7, IDH1/IDH2 inhibitor

COA COA
In stock
Item Number
V305105
Grouped product items
SKU Size
Availability
 Price Qty
V305105-1mg
1mg
3
$35.90
V305105-5mg
5mg
3
$147.90
V305105-10mg
10mg
2
$246.90
V305105-25mg
25mg
2
$555.90
V305105-50mg
50mg
2
$741.90
V305105-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,088.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Isocitrate Dehydrogenase (IDH) (30) isocitrate dehydrogenase (NADP(+)) 1 Inhibitor (6) isocitrate dehydrogenase (NADP(+)) 2 Inhibitor (3) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms 6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | AG 881 [WHO-DD] | C73178 | Vorasidenib [INN] | 6-(6-chloropyridin-2-yl)-N~2~,N~4~-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | BDBM2799
Specifications & Purity Moligand™, ≥98%
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action IDH1/IDH2 inhibitor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Triazines
Subclass Aminotriazines
Intermediate Tree Nodes Not available
Direct Parent 1,3,5-triazine-2,4-diamines
Alternative Parents Secondary alkylarylamines  N-aliphatic s-triazines  2-halopyridines  Aryl chlorides  1,3,5-triazines  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organofluorides  Organochlorides  Hydrocarbon derivatives  Alkyl fluorides  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents 2,4-diamine-s-triazine - 2-halopyridine - N-aliphatic s-triazine - Secondary aliphatic/aromatic amine - 1,3,5-triazine - Pyridine - Aryl halide - Aryl chloride - Heteroaromatic compound - Azacycle - Secondary amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as 1,3,5-triazine-2,4-diamines. These are aromatic compounds containing a 1,3,5-triazine ring which is 2,4-disusbtituted wit amine groups.
External Descriptors Not available

Product Properties

ALogP 5.3

Associated Targets(Human)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (4 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IDH2 Tclin Isocitrate dehydrogenase [NADP], mitochondrial (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HT-1080 (3966 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-87 MG (3946 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504772836
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772836
IUPAC Name 6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine
INCHI InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1
InChIKey QCZAWDGAVJMPTA-RNFRBKRXSA-N
Smiles CC(C(F)(F)F)NC1=NC(=NC(=N1)C2=NC(=CC=C2)Cl)NC(C)C(F)(F)F
Isomeric SMILES C[C@H](C(F)(F)F)NC1=NC(=NC(=N1)C2=NC(=CC=C2)Cl)N[C@H](C)C(F)(F)F
PubChem CID 117817422
Molecular Weight 414.74

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
C2528290 Certificate of Analysis Apr 03, 2025 V305105
A2219685 Certificate of Analysis Nov 04, 2024 V305105
A2219524 Certificate of Analysis Nov 04, 2024 V305105
A2219683 Certificate of Analysis Nov 04, 2024 V305105
A2219525 Certificate of Analysis Nov 04, 2024 V305105
A2219526 Certificate of Analysis Nov 04, 2024 V305105
A2219686 Certificate of Analysis Nov 04, 2024 V305105

Chemical and Physical Properties

Molecular Weight 414.740 g/mol
XLogP3 5.300
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 12
Rotatable Bond Count 5
Exact Mass 414.079 Da
Monoisotopic Mass 414.079 Da
Topological Polar Surface Area 75.600 Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 448.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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