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Vitamin K1 - 10mM in DMSO, high purity , CAS No.84-80-0

    Grade & Purity:
  • 10mM in DMSO
In stock
Item Number
V426219
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Availability
Price Qty
V426219-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$82.90

Basic Description

Synonyms Phylloquinone | Vitamin K1 | phytonadione | 84-80-0 | Phytomenadione | Phytylmenadione | 3-Phytylmenadione | Aquamephyton | Phyllochinon | Konakion | Mephyton | Monodion | Synthex P | 2-Methyl-3-phytyl-1,4-naphthoquinone | Mono-Kay | Fitomenadiona | Phyllochinonum | Phytomenadionum | Phyton
Specifications & Purity 10mM in DMSO
Biochemical and Physiological Mechanisms Vitamin K1 plays a role as a cofactor in the synthesis of γ- carboxy glutamate (Gla), formation of coagulation factors II (prothrombin), VII, IX and X.
Storage Temp Protected from light,Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Vitamin K1, also known as phylloquinone, consists of naphthalenoid and phytyl groups. Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source. It is a fat-soluble vitamin.

Vitamin K{1} is an important dietary source found in green plants, algae and photosynthetic bacteria. It is used as a vitamin (prothrombogenic) and veterinary antidote for dicoumarol poisoning. It is an essential vitamin for the synthesis of coagulation factors II, VII, IX, and X in the liver.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Prenol lipids
Subclass Quinone and hydroquinone lipids
Intermediate Tree Nodes Not available
Direct Parent Vitamin K compounds
Alternative Parents Diterpenoids  Naphthoquinones  Quinones  Aryl ketones  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic homopolycyclic compounds
Substituents Diterpenoid - Naphthoquinone - Naphthalene - Aryl ketone - Quinone - Benzenoid - Ketone - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aromatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as vitamin k compounds. These are quinone lipids containing a methylated naphthoquinone ring structure, and vary in the aliphatic side chain attached at the 3-position.
External Descriptors Vitamin K

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR1I2 Tchem Pregnane X receptor (6667 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Raji (5516 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLH Tchem DNA polymerase eta (21678 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Ttr Transthyretin (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
INCHI InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
InChIKey MBWXNTAXLNYFJB-NKFFZRIASA-N
Smiles CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C
Isomeric SMILES CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C
WGK Germany 2
RTECS QJ5800000
Alternate CAS 12001-79-5
Molecular Weight 450.7
Beilstein 2568820
Reaxy-Rn 2568816

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity Light sensitive.Heat and Moisture Sensitive
Refractive Index 1.5263
Flash Point(°F) >235.4 °F
Flash Point(°C) >109.9 °C
Boil Point(°C) 140-145 °C/0.0013 hPa
Melt Point(°C) -20 °C
Molecular Weight 450.700 g/mol
XLogP3 10.900
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 14
Exact Mass 450.35 Da
Monoisotopic Mass 450.35 Da
Topological Polar Surface Area 34.100 Ų
Heavy Atom Count 33
Formal Charge 0
Complexity 696.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 1
Covalently-Bonded Unit Count 1

Citations of This Product

1. Hongpeng Wang, Ruibin Bai, Danqi Hu, Wenxin Chen, Zhuqian Xiao, Jun Huang, Xiufu Wan, Jian Yang, Xuelan Yu.  (2023)  Structure analysis and in vitro evaluation of probiotic properties for polysaccharides from Phellinus baumii extracted with phosphotungstic acid assistance.  LWT-FOOD SCIENCE AND TECHNOLOGY,  188  (115367). 
2. Qinghua Cao, Xiang Xiao, Chengcheng Tao, Rui Shi, Rui Lv, Ruochen Guo, Xinyi Li, Baiyan Sui, Xin Liu, Jian Liu.  (2023)  Efficient clearance of periodontitis pathogens by S. gordonii membrane-coated H2O2 self-supplied nanocomposites in a “Jenga” style.  Biomaterials Science,     
3. Bowen Qin, Yijun Yao, Jing Zhang, Lifeng Wang.  (2023)  Bioavailability of Coix Seed Polyphenols in a MKN28/Caco-2 Continuous Transport Model and Their Lipid-Lowering Effects via Modulating Adipocyte Differentiation of 3T3-L1 Cells.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (22): (8425–8436). 
4. Linlin Gao, Lin Zhang, Huan Liu, Jielun Hu.  (2023)  In vitro gastrointestinal digestion of whole grain noodles supplemented with soluble dietary fiber and their effects on children fecal microbiota.  Food Bioscience,  53  (102600). 
5. Sun Hanyu, Li Pugeng, Kong Qingci, Deng Feilong, Yu Xiaolin.  (2023)  Zoledronic acid affects the process of Porphyromonas gingivalis infecting oral mucosal epithelial barrier: An in-vivo and in-vitro study.  Frontiers in Cellular and Infection Microbiology,  13   
6. Ke Lan, Huabing Yang, Junping Zheng, Haiming Hu, Tianxiang Zhu, Xiaojuan Zou, Baifei Hu, Hongtao Liu.  (2023)  Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis.  Food & Function,  14  (2): (857-873). 
7. Yulian Chen, Qian Zhang, Xuan Qin, Jin Li, Yantao Zhao, Yang Xia.  (2022)  Superparamagnetic Iron Oxide Nanoparticles Protect Human Gingival Fibroblasts from Porphyromonas gingivalis Invasion and Inflammatory Stimulation.  International Journal of Nanomedicine,     
8. Zhijia Wang, Wen Li, Jihui Lu, Zhihua Yuan, Wenmin Pi, Yaozhi Zhang, Haimin Lei, Wenguang Jing, Penglong Wang.  (2023)  Revealing the active ingredients of the traditional Chinese medicine decoction by the supramolecular strategies and multitechnologies.  JOURNAL OF ETHNOPHARMACOLOGY,  300  (115704). 
9. Yun-Shan Wei, Kun Feng, Shu-Fang Li, Teng-Gen Hu, Min-Hua Zong, Hong Wu.  (2022)  Highly-hydrophobic nanofiber mat for efficient colonic delivery of lactoferrin: Preparation, characterization and release mechanism.  Innovative Food Science & Emerging Technologies,  78  (103015). 
10. Xueting Guan, Yujing Feng, Yunyao Jiang, Yeye Hu, Ji Zhang, Zhengpeng Li, Chao Song, Fu Li, Jincai Hou, Ting Shen, Weicheng Hu.  (2022)  Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.) root residue by the human gut microbiota.  FOOD RESEARCH INTERNATIONAL,  155  (111074). 
11. Peilin Chen, Suzhen Lei, Mingyao Tong, Qing Chang, Baodong Zheng, Yi Zhang, Hongliang Zeng.  (2022)  Effect of polysaccharide fractions from Fortunella margarita on the fecal microbiota of mice and SCFA production in vitro.  Food Science and Human Wellness,  11  (97). 
12. Song Li, Baojie Zhang, Jielun Hu, Yadong Zhong, Yonggan Sun, Shaoping Nie.  (2021)  Utilization of four galactans by Bacteroides thetaiotaomicron A4 based on transcriptome.  Food Frontiers,  (2): (218-231). 
13. Li-na Xu, Xiao-yu Yu, Wan-qing Chen, Song-mei Zhang, Jing Qiu.  (2020)  Biocorrosion of pure and SLA titanium surfaces in the presence of Porphyromonas gingivalis and its effects on osteoblast behavior.  RSC Advances,  10  (14): (8198-8206). 
14. Xiao-Fei Shang, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Ying-Qian Liu, Li-Xia Dai, Zhi-Jun Zhang, Zhi-Gang Yang, Xiao-Lou Miao, Cheng-Jie Yang, Ji-Yu Zhang.  (2019)  Insecticidal and antifungal activities of Rheum palmatum L. anthraquinones and structurally related compounds.  INDUSTRIAL CROPS AND PRODUCTS,  137  (508). 
15. Benkai Qin, Lei Liu, Yangyang Pan, Yingchun Zhu, Xiaohe Wu, Shiyong Song, Guang Han.  (2017)  PEGylated Solanesol for Oral Delivery of Coenzyme Q10.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  65  (16): (3360–3367). 
16. Xiao-Fei Shang,Ying-Qian Liu,Xiao Guo,Xiao-Lou Miao,Cheng Chen,Jun-Xiang Zhang,Xiao-Shan Xu,Guan-Zhou Yang,Cheng-Jie Yang,Jun-Cai Li,Xiao-Shuai Zhang.  (2018-01-27)  Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi..  Scientific reports,  ((1)): (1609-1609). 
17. Huayang Si, Yimeng Chen, Dejun Hu, Sainan Yao, Jie Yang, Xiaodong Wen.  (2024)  A graminan type fructan from Achyranthes bidentata prevents the kidney injury in diabetic mice by regulating gut microbiota.  CARBOHYDRATE POLYMERS,  339  (122275). 
18. You Zhou, Zhe Shen, Yan Xu, Xin-na Qian, Wei Chen, Jing Qiu.  (2024)  Antimicrobial efficiency and cytocompatibility of resveratrol and naringin as chemical decontaminants on SLA surface.  Microbiology Spectrum,     
19. Wenyu Cui, Fuchun Chen, Zhaoyue Sun, Caifang Cui, Ben Xu, Weijun Shen, Fachun Wan, Anwei Cheng.  (2024)  Catabolism of phenolics from grape peel and its effects on gut microbiota during in vitro colonic fermentation.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,     
20. Zhenhua Yin, Juanjuan Zhang, Qingfeng Guo, Jiale Zhi, Xia Zhang, Wei Zhang, Lin Chen.  (2024)  Characteristics of polysacchadride from Psoralea corylifolia in simulated gastrointestinal digestion and microbial fermentation.  Journal of Functional Foods,  122  (106549). 
21. Meng Zhang, Pengfei Du, Jin Wan, Yimeng Chen, Xin Chen, Yumei Zhang.  (2024)  Effects of sodium dehydroacetate on broiler chicken bones.  POULTRY SCIENCE,  103  (103834). 
22. Tao Sun, Xiaoning Liang, Xiaoyi Xu, Linhao Wang, Wei Xiao, Yuhang Ma, Rui Wang, Yian Gu, Sha Li, Yibin Qiu, Dafeng Sun, Hong Xu, Peng Lei.  (2024)  In vitro digestion and fecal fermentation of basidiospore-derived exopolysaccharides from Naematelia aurantialba.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  261  (129756). 
23. Song Li, Xiaomao Peng, Zengbo Wang, Chunhua Chen, Xin Li, Qixing Nie, Xiaojun Huang, Shuigen Bian, Junyi Yin, Steve W. Cui, Huizi Tan, Shaoping Nie.  (2025)  Interaction between Bacteroides and HG-type pectins with different molecular weights.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (142363). 
24. Cui Cao, Yiping Gao, Feilong Sun, Chunqing Ai, Shuang Song.  (2024)  Lycium barbarum arabinogalactan inhibits Escherichia coli and improves Lactobacillus plantarum growth in a defined microbial model of human gut microbiome.  Food Bioscience,  62  (105168). 
25. Ting Pan, Yixue Li, Feng-Shou Liu, Huancai Lin, Yan Zhou.  (2024)  Membrane-Anchored Aggregation-Induced Emission Luminogens: Accurate Labeling and Efficient Photodynamic Inactivation of Streptococcus mutans in Anticaries Therapy.  ACS Applied Materials & Interfaces,  16  (24): (30833-30846). 
26. Zhiqing Xie, Aohuan Huang, Jihang Xie, Shubo Yu, Mengfei Chen, Jie Cai, Rong Huang, Zhenjun Zhu, Yu Ding.  (2024)  Rapid identification of Bacteroides dorei using novel specific target revealed by pan-genome analysis and its application in food.  LWT-FOOD SCIENCE AND TECHNOLOGY,  206  (116557). 
27. Yun-shan Wei, Kun Feng, Hong Wu.  (2024)  Regulation of the colon-targeted release rate of lactoferrin by constructing hydrophobic ethyl cellulose/pectin composite nanofibrous carrier and its effect on anti-colon cancer activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  261  (129466). 
28. Haiyan Wang, Zhenyu Yang, Shuxia Wang, Huwei Wu, Xuehong Pang, Yichun Hu, Xiaoguang Yang.  (2024)  Study on Vitamin K Levels in Mature Milk of Chinese Lactating Mothers.  Nutrients,  16  (19): (3351). 
29. Dai Xiaochan, Yang Xi, Feng Yifan, Wu Xinyuan, Ju Yahan, Zou Rong, Yuan Fei.  (2025)  The role of vitamin K and its antagonist in the process of ferroptosis-damaged RPE-mediated CNV.  Cell Death & Disease,  16  (1): (1-15). 

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