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Vacuolin-1 - ≥95%, high purity , CAS No.351986-85-1

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Vacuolin-1 - ≥95%, high purity , CAS No.351986-85-1

COA

Grade & Purity:

≥95%

Cas Number: 351986-85-1
Molecular Weight: 577.42
PubChem CID: 9661141
PubChem SID: 504764842

In stock

Item Number

V336926

Grouped product items
SKU	Size	Availability	Price
V336926-5mg	5mg	3	$88.90
V336926-10mg	10mg	3	$137.90
V336926-25mg	25mg	3	$310.90
V336926-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$771.90
V336926-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,737.90

a cell-permeable triazine that inhibits Ca2+-dependent fusion of lysosomes to the cell membrane inhibiting release of lysosomal content.

View related series

Autophagy (1917) PI3K/Akt/mTOR (765) PIKfyve (9)

Basic Description

Synonyms	4-[(2E)-2-(3-iodobenzylidene)hydrazinyl]-6-(morpholin-4-yl)-N,N-diphenyl-1,3,5-triazin-2-amine \| BDBM50595937 \| J-019992 \| 2-N-[(E)-(3-iodophenyl)methylideneamino]-6-morpholin-4-yl-4-N,4-N-diphenyl-1,3,5-triazine-2,4-diamine \| 4-(2-(3-Iodobenzylidene)hydr
Specifications & Purity	≥95%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Vacuolin-1 is a lysosomal exocytosis inhibitor that prevents Ca\|2+\|-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content. Vacuolin-1 alters the morphology of lysosomes, but not their cell resealing. Vacuolin-1 is cell-permeable. Vacuolin-1 does not disturb the organization of the actin or tubulin cytoskeletal networks. Vacuolin-1 also does not interfere with trafficking along the endocytic or secretory pathways.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Triazines
    - Subclass Aminotriazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Triazines
Subclass	Aminotriazines
Intermediate Tree Nodes	Not available
Direct Parent	1,3,5-triazine-2,4-diamines
Alternative Parents	Dialkylarylamines Aniline and substituted anilines Iodobenzenes Morpholines Aryl iodides 1,3,5-triazines Heteroaromatic compounds Oxacyclic compounds Hydrazones Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organoiodides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2,4-diamine-s-triazine - Aniline or substituted anilines - Dialkylarylamine - Halobenzene - Iodobenzene - Aryl halide - Aryl iodide - Monocyclic benzene moiety - Morpholine - 1,3,5-triazine - Benzenoid - Oxazinane - Heteroaromatic compound - Dialkyl ether - Ether - Hydrazone - Oxacycle - Azacycle - Organopnictogen compound - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Organohalogen compound - Organoiodide - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 1,3,5-triazine-2,4-diamines. These are aromatic compounds containing a 1,3,5-triazine ring which is 2,4-disusbtituted wit amine groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

MCF7 (126967 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PC-3 (62116 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIKFYVE Tchem 1-phosphatidylinositol 3-phosphate 5-kinase (270 Activities)

Discover Target: PIKFYVE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504764842
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504764842
IUPAC Name	2-N-[(E)-(3-iodophenyl)methylideneamino]-6-morpholin-4-yl-4-N,4-N-diphenyl-1,3,5-triazine-2,4-diamine
INCHI	InChI=1S/C26H24IN7O/c27-21-9-7-8-20(18-21)19-28-32-24-29-25(33-14-16-35-17-15-33)31-26(30-24)34(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-13,18-19H,14-17H2,(H,29,30,31,32)/b28-19+
InChIKey	JMEJTSRAQUFNOP-TURZUDJPSA-N
Smiles	C1COCCN1C2=NC(=NC(=N2)NN=CC3=CC(=CC=C3)I)N(C4=CC=CC=C4)C5=CC=CC=C5
Isomeric SMILES	C1COCCN1C2=NC(=NC(=N2)N/N=C/C3=CC(=CC=C3)I)N(C4=CC=CC=C4)C5=CC=CC=C5
RTECS	WS5697000
PubChem CID	9661141
Molecular Weight	577.42

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
F2220422	Certificate of Analysis	Apr 03, 2025	V336926
F2220441	Certificate of Analysis	Apr 03, 2025	V336926
F2220442	Certificate of Analysis	Apr 03, 2025	V336926
F2220427	Certificate of Analysis	Apr 03, 2025	V336926
F2220580	Certificate of Analysis	Apr 03, 2025	V336926

Chemical and Physical Properties

Solubility	Soluble in DMSO (1 mM).
Boil Point(°C)	719.71° C at 760 mmHg (Predicted)
Molecular Weight	577.400 g/mol
XLogP3	6.200
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Exact Mass	577.109 Da
Monoisotopic Mass	577.109 Da
Topological Polar Surface Area	78.800 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	634.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

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