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USP8-IN-3 - 99%, high purity , CAS No.2477651-10-6

COA

Grade & Purity:

≥99%

Cas Number: 2477651-10-6
Molecular Weight: 425.43

In stock

Item Number

U648417

Grouped product items
SKU	Size	Availability	Price
U648417-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$130.90
U648417-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$210.90
U648417-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$440.90
U648417-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
U648417-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,100.90

View related series

Cell Cycle/DNA Damage (2602) Deubiquitinase (86) Unfolded Protein Response (214)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC 50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI 50 s of 37.03 μM and 6.01 μM, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC 50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI 50 s of 37.03 μM and 6.01 μM, respectively In Vitro USP8-IN-3 (6.25-100 μM; 15 min) inhibits the cleavage activity of USP8 on diubiquitin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: / Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, and 100 μM Incubation Time: 15 min; added Di-Ub substrate for another 1 h Result: Decreased the cleaved diubiquitin level. Form:Solid IC50& Target:USP8 4.0 μM (IC 50 )

Names and Identifiers

Smiles	[O-][N+](C1=CC=C(NC(NC2CCN(CC2)C3=CC=CC(C(F)(F)F)=N3)=S)C=C1)=O
Molecular Weight	425.43

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