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Small Molecules & Compound Libraries
Signaling Pathways
Cell Cycle/DNA Damage
Deubiquitinase
USP25/28 inhibitor AZ1 - 98%, high purity , CAS No.2165322-94-9

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USP25/28 inhibitor AZ1 - 98%, high purity , CAS No.2165322-94-9

COA

Grade & Purity:

≥98%

Cas Number: 2165322-94-9
Molecular Weight: 422.21
PubChem CID: 135397656
PubChem SID: 504773217

In stock

Item Number

U414259

Grouped product items
SKU	Size	Availability	Price
U414259-5mg	5mg	3	$147.90
U414259-25mg	25mg	3	$494.90
U414259-50mg	50mg	3	$840.90
U414259-100mg	100mg	3	$1,434.90
U414259-250mg	250mg	3	$3,228.90

USP/UBP Selective Inhibitors

View related series

Cell Cycle/DNA Damage (2602) Deubiquitinase (86) Unfolded Protein Response (214)

Basic Description

Synonyms	AZ1 \| 2-[[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]-Ethanol
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	AZ1 is a potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information AZ1 is a potent and noncompetitive dual Inhibitors of theubiquitin-specific protease (USP) 25/28with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively. Targets USP25 (Cell-free assay); USP28 (Cell-free assay) 0.62 μM; 0.7 μM In vitro AZ1 is able to reduce cell viability across a range of cancer cell lines with EC50 values typically clustered around 20 μM.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Trifluoromethylbenzenes

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Trifluoromethylbenzenes
Intermediate Tree Nodes	Not available
Direct Parent	Trifluoromethylbenzenes
Alternative Parents	Phenoxy compounds Phenol ethers Fluorobenzenes Bromobenzenes Alkyl aryl ethers Dialkylamines Alkanolamines Organopnictogen compounds Organofluorides Organobromides Hydrocarbon derivatives Alkyl fluorides Alcohols and polyols
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Trifluoromethylbenzene - Phenoxy compound - Phenol ether - Halobenzene - Fluorobenzene - Bromobenzene - Alkyl aryl ether - Secondary amine - Ether - Secondary aliphatic amine - Alkanolamine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organobromide - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Alcohol - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as trifluoromethylbenzenes. These are organofluorine compounds that contain a benzene ring substituted with one or more trifluoromethyl groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	4.291
HBD Count	2
Rotatable Bond	8

Associated Targets(Human)

USP28 Tchem Ubiquitin carboxyl-terminal hydrolase 28 (1 Activities)

Discover Target: USP28

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP28 Tchem Ubiquitin carboxyl-terminal hydrolase 28 (268 Activities)

Discover Target: USP28

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504773217
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773217
IUPAC Name	2-[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methylamino]ethanol
INCHI	InChI=1S/C17H16BrF4NO2/c18-13-2-4-16(12(8-13)9-23-5-6-24)25-10-11-1-3-15(19)14(7-11)17(20,21)22/h1-4,7-8,23-24H,5-6,9-10H2
InChIKey	ITHSFXDGKQYOED-UHFFFAOYSA-N
Smiles	C1=CC(=C(C=C1COC2=C(C=C(C=C2)Br)CNCCO)C(F)(F)F)F
Isomeric SMILES	C1=CC(=C(C=C1COC2=C(C=C(C=C2)Br)CNCCO)C(F)(F)F)F
PubChem CID	135397656
Molecular Weight	422.21

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
C2303339	Certificate of Analysis	Sep 26, 2022	U414259
C2303422	Certificate of Analysis	Sep 26, 2022	U414259
C2303418	Certificate of Analysis	Sep 26, 2022	U414259
C2303340	Certificate of Analysis	Sep 26, 2022	U414259
C2303341	Certificate of Analysis	Sep 26, 2022	U414259

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 84 mg/mL (198.95 mM); Ethanol: 84 mg/mL (198.95 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	84
DMSO(mM) Max Solubility	198.953127590536
Water(mg / mL) Max Solubility	＜1
Molecular Weight	422.200 g/mol
XLogP3	3.700
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	421.03 Da
Monoisotopic Mass	421.03 Da
Topological Polar Surface Area	41.500 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	399.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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