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Urolithin A - ≥98%(HPLC), high purity , CAS No.1143-70-0

4 Citations COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
U287598
Grouped product items
SKU Size
Availability
 Price Qty
U287598-10mg
10mg
3
$13.90
U287598-100mg
100mg
3
$33.90
U287598-250mg
250mg
3
$66.90
U287598-1g
1g
2
$166.90
U287598-5g
5g
3
$533.90
U287598-25g
25g
2
$1,666.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6Kin vitro

View related series
Apoptosis (4276) Autophagy (1917) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) DNA/RNA Synthesis (362) Drug Metabolite (241) Endogenous Metabolite (959) Glucose Metabolism (1943) Immunology/Inflammation (1929) Metabolic Enzyme/Protease (4860) Metabolite (5307) NF-κB (747) Reactive Oxygen Species (309)

Basic Description

Synonyms 3,8-Dihydroxyurolithin | 3,8-dihydroxy-urolithin | FT-0778244 | 3,8-dihydroxy-6h-dibenzo[b,d]pyran-6-one | 3,8-Dihydroxy-6H-dibenzo(b,d)pyran-6-one | CHEBI:168442 | 6H-Dibenzo[b,d]pyran-6-one, 3,8-dihydroxy- | A901528 | AC-31959 | ILJ8NEF6DT | SY070232 |
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell linesin vitro(IC50values are 10.23 - 62.28 μM). Supp
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Coumarins and derivatives
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Coumarins and derivatives
Alternative Parents Isocoumarins and derivatives  2-benzopyrans  1-benzopyrans  Pyranones and derivatives  1-hydroxy-2-unsubstituted benzenoids  Heteroaromatic compounds  Lactones  Oxacyclic compounds  Organooxygen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Coumarin - Isocoumarin - Benzopyran - 1-benzopyran - 2-benzopyran - 1-hydroxy-2-unsubstituted benzenoid - Pyranone - Pyran - Benzenoid - Heteroaromatic compound - Lactone - Oxacycle - Organoheterocyclic compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).
External Descriptors Not available

Associated Targets(non-human)

Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasma (328 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504763884
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504763884
IUPAC Name 3,8-dihydroxybenzo[c]chromen-6-one
INCHI InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
InChIKey RIUPLDUFZCXCHM-UHFFFAOYSA-N
Smiles C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
Isomeric SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
PubChem CID 5488186
Molecular Weight 228.20

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

21 results found

Lot Number Certificate Type Date Item
A2522269 Certificate of Analysis Jan 13, 2025 U287598
A2522272 Certificate of Analysis Jan 13, 2025 U287598
A2522267 Certificate of Analysis Jan 13, 2025 U287598
A2522274 Certificate of Analysis Jan 13, 2025 U287598
B2507237 Certificate of Analysis Jan 13, 2025 U287598
J2228749 Certificate of Analysis Oct 19, 2022 U287598
J2228750 Certificate of Analysis Oct 19, 2022 U287598
D2422069 Certificate of Analysis Oct 19, 2022 U287598
J2412034 Certificate of Analysis Oct 19, 2022 U287598
J2228742 Certificate of Analysis Oct 19, 2022 U287598
J2228744 Certificate of Analysis Oct 19, 2022 U287598
J2228740 Certificate of Analysis Oct 19, 2022 U287598
J2228745 Certificate of Analysis Oct 19, 2022 U287598
J2228751 Certificate of Analysis Oct 19, 2022 U287598
J2330076 Certificate of Analysis Oct 19, 2022 U287598
J2429067 Certificate of Analysis Oct 19, 2022 U287598
E2422127 Certificate of Analysis Oct 19, 2022 U287598
C2427088 Certificate of Analysis Oct 19, 2022 U287598
L2416372 Certificate of Analysis Oct 19, 2022 U287598
F2215111 Certificate of Analysis Jun 21, 2022 U287598
F2220042 Certificate of Analysis Jun 20, 2022 U287598

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Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 22.82, Max Conc. mM: 100
Molecular Weight 228.200 g/mol
XLogP3 2.300
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 0
Exact Mass 228.042 Da
Monoisotopic Mass 228.042 Da
Topological Polar Surface Area 66.800 Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 317.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. Urolithin A
    Urolithin A
    • 10mM in DMSO

    Starting at $252.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Yang Yang, Pui-Kei Lee, Ho-Ching Wong, Danyue Zhao.  (2024)  Oral supplementation of Gordonibacter urolithinfaciens promotes ellagic acid metabolism and urolithin bioavailability in mice.  FOOD CHEMISTRY,  437  (137953). 
2. Zeyuan Jin, Yaqi Zhang, Haijun Hu, Qian Li, Liwen Zhang, Kefei Zhao, Wenxing Liu, Lanjuan Li, Changyou Gao.  (2024)  Closed-Loop Theranostic Microgels for Immune Microenvironment Modulation and Microbiota Remodeling in Ulcerative Colitis.  BIOMATERIALS,    (122834). 
3. Huang Zhengyuan, Ren Zhongyu, Wang Sanwang, Xiao Ling, Ling Yipeng, Xie Yinping, Wang Gaohua, Zhou Benhong.  (2025)  Urolithin A alleviates schizophrenic-like behaviors and cognitive impairment in rats through modulation of neuroinflammation, neurogenesis, and synaptic plasticity.  Scientific Reports,  15  (1): (1-15). 
4. Zhengyuan Huang, Guanghui Chen, Zhongyu Ren, Ling Xiao, Ziyue Chen, Yinping Xie, Gaohua Wang, Benhong Zhou.  (2025)  Urolithin A ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling.  INTERNATIONAL IMMUNOPHARMACOLOGY,  151  (114336). 

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