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UDP , CAS No.58-98-0, Agonist of GPR17;Activator of K ir6.1;Agonist of P2Y 14 receptor;Agonist of P2Y 6 receptor

5 Citations COA COA
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Item Number
U614634
Grouped product items
SKU Size
Availability
 Price Qty
U614634-25μg
25μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$560.90
U614634-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,500.90
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Class A GPCR (4138) GPR17 Agonist (10) Kir6.1 Activator (8) Metabolite (5307) P2Y14 receptor Agonist (7) P2Y6 receptor Agonist (13)

Basic Description

Synonyms CHEBI:17659 | UDP | ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyltrihydrogendiphosphate | EINECS 200-409-6 | SCHEMBL4245 | 5G0F599A1Y | uridine-5'-diphosphate | uridine 5''-(trihydrogen diphosphate) |
Specifications & Purity Moligand™
Grade Moligand™
Action Type ACTIVATOR, AGONIST
Mechanism of action Agonist of GPR17;Activator of K ir6.1;Agonist of P2Y 14 receptor;Agonist of P2Y 6 receptor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Nucleosides, nucleotides, and analogues
Class Pyrimidine nucleotides
Subclass Pyrimidine ribonucleotides
Intermediate Tree Nodes Not available
Direct Parent Pyrimidine ribonucleoside diphosphates
Alternative Parents Pentose phosphates  Glycosylamines  Organic pyrophosphates  Monosaccharide phosphates  Pyrimidones  Monoalkyl phosphates  Hydroxypyrimidines  Hydropyrimidines  Tetrahydrofurans  Heteroaromatic compounds  Secondary alcohols  1,2-diols  Oxacyclic compounds  Azacyclic compounds  Hydrocarbon derivatives  Organic oxides  Organonitrogen compounds  Organopnictogen compounds  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Pyrimidine ribonucleoside diphosphate - Pentose phosphate - Pentose-5-phosphate - Glycosyl compound - N-glycosyl compound - Monosaccharide phosphate - Organic pyrophosphate - Hydroxypyrimidine - Pyrimidone - Monoalkyl phosphate - Hydropyrimidine - Monosaccharide - Organic phosphoric acid derivative - Phosphoric acid ester - Pyrimidine - Alkyl phosphate - Heteroaromatic compound - Tetrahydrofuran - Secondary alcohol - 1,2-diol - Oxacycle - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Alcohol - Organopnictogen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as pyrimidine ribonucleoside diphosphates. These are pyrimidine ribonucleotides with diphosphate group linked to the ribose moiety.
External Descriptors Ribonucleotides

Associated Targets(Human)

GPR17 Tchem Uracil nucleotide/cysteinyl leukotriene receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNJ8 Tbio ATP-sensitive inward rectifier potassium channel 8 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
P2RY6 Tchem P2Y purinoceptor 6 (9 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
P2RY14 Tchem P2Y purinoceptor 14 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY6 Tchem Pyrimidinergic receptor P2Y6 (717 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY4 Tchem Pyrimidinergic receptor P2Y4 (598 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY1 Tchem Purinergic receptor P2Y1 (1327 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAD Tchem Dihydroorotase (27 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY2 Tclin Purinergic receptor P2Y2 (1109 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RY14 Tchem Purinergic receptor P2Y14 (692 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RNASE1 Tchem Ribonuclease pancreatic (45 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ENPP3 Tchem Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (241 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ENPP1 Tchem Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (635 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OGT Tchem UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (206 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GPR17 Tchem Uracil nucleotide/cysteinyl leukotriene receptor (291 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Iap Intestinal alkaline phosphatase (419 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
glf UDP-galactopyranose mutase (153 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Serum (58 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SRN Seminal ribonuclease (5 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2ry14 P2Y purinoceptor 14 (107 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
INCHI InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKey XCCTYIAWTASOJW-XVFCMESISA-N
Smiles O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Isomeric SMILES C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)O)O)O
PubChem CID 6031

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Molecular Weight 404.160 g/mol
XLogP3 -4.700
Hydrogen Bond Donor Count 6
Hydrogen Bond Acceptor Count 12
Rotatable Bond Count 6
Exact Mass 404.002 Da
Monoisotopic Mass 404.002 Da
Topological Polar Surface Area 212.000 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 675.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Lai Liang, Zhang Mengyun, Liu Chusheng, Qu Jiahuan, Xu Dongsheng, Jiang Zhengjin.  (2023)  A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation.  ANALYTICAL SCIENCES,    (1-7). 
2. Tao Chen, Qi Wang, Qiqi Wang, Mencuo La, Yulin Li, Liangliang He, Denglang Zou.  (2022)  Ab initio calculation based solvent system selection in silico for counter-current chromatography: Separation of resibufogenin glycosylation products.  JOURNAL OF CHROMATOGRAPHY A,  1686  (463649). 
3. Denglang Zou, Yunbin Cui, Si Li, Duocheng Sang, Weimeng Liu, Tianshu Zhao, Xueli Gu, Tao Chen, Yulin Li.  (2021)  The applicability of high-speed counter-current chromatography for preparative separation of biosynthesis products: Glycosylation products as example.  JOURNAL OF SEPARATION SCIENCE,  44  (24): (4368-4375). 
4. Qiqi Wang, Tao Chen, Yunbin Cui, Si Li, Xinhao Jiang, Guodong Zhao, Yulin Li, Denglang Zou.  (2021)  The applicability of pH-zone-refining counter-current chromatography for preparative separation of biosynthesis products: Glycosylation products as example.  JOURNAL OF CHROMATOGRAPHY A,  1657  (462582). 
5. Guimei Wang, Xiaoxue Jiang, Nanyan Fu.  (2019)  Near-infrared squaraine fluorescent probe for imaging adenosine 5′-triphosphate in live cells.  DYES AND PIGMENTS,  171  (107698). 

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