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UCM 608 - ≥98%(HPLC), high purity , CAS No.151889-03-1

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
P288352
Grouped product items
SKU Size
Availability
 Price Qty
P288352-5mg
5mg
2
$98.90
P288352-10mg
10mg
3
$157.90
P288352-25mg
25mg
2
$315.90
P288352-50mg
50mg
2
$513.90
P288352-100mg
100mg
2
$820.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent melatonin agonist

View related series
Class A GPCR (4138) GPCR/G Protein (3172) Melatonin Receptor (28) Neuronal Signaling (3320)

Basic Description

Synonyms UCM608;UCM-608 | CHEBI:107661 | Q27185983 | UCM 608 | N-[2-(5-METHOXY-2-PHENYLINDOL-3-YL)ETHYL]ACETAMIDE | AM20030035 | PDSP2_001778 | SR-01000597657 | NCGC00024727-02 | HMS3675O18 | PDSP1_001796 | HY-101074 | Tocris-0680 | BRD-K41869275-001-01-0 | Melato
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC50values for G protein activation in MT1and MT2-transfected cells are 65 and 58 pM respectively.
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Product Describtion:

UCM 608 is a high affinity melatonin (MT) membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Indoles and derivatives
Subclass Indoles
Intermediate Tree Nodes Not available
Direct Parent 2-phenylindoles
Alternative Parents Phenylpyrroles  N-acetyl-2-arylethylamines  3-alkylindoles  Anisoles  Alkyl aryl ethers  Benzene and substituted derivatives  Heteroaromatic compounds  Secondary carboxylic acid amides  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents 2-phenylindole - 2-phenylpyrrole - N-acetyl-2-arylethylamine - 3-alkylindole - Anisole - Alkyl aryl ether - Monocyclic benzene moiety - Substituted pyrrole - Benzenoid - Pyrrole - Heteroaromatic compound - Acetamide - Secondary carboxylic acid amide - Carboxamide group - Ether - Carboxylic acid derivative - Azacycle - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as 2-phenylindoles. These are indoles substituted at the 2-position with a phenyl group.
External Descriptors Not available

Associated Targets(Human)

MTNR1A Tclin Melatonin receptor 1A (2519 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MTNR1A Tclin Melatonin receptor (989 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Melatonin receptor 1B (19 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488194651
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488194651
IUPAC Name N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide
INCHI InChI=1S/C19H20N2O2/c1-13(22)20-11-10-16-17-12-15(23-2)8-9-18(17)21-19(16)14-6-4-3-5-7-14/h3-9,12,21H,10-11H2,1-2H3,(H,20,22)
InChIKey OFCLARYYBGKCHN-UHFFFAOYSA-N
Smiles CC(=O)NCCC1=C(NC2=C1C=C(C=C2)OC)C3=CC=CC=C3
Isomeric SMILES CC(=O)NCCC1=C(NC2=C1C=C(C=C2)OC)C3=CC=CC=C3
PubChem CID 4018512
Molecular Weight 308.38

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
D2311688 Certificate of Analysis Feb 28, 2023 P288352
D2311710 Certificate of Analysis Feb 28, 2023 P288352
D2311697 Certificate of Analysis Feb 28, 2023 P288352
D2311711 Certificate of Analysis Feb 28, 2023 P288352
D2311726 Certificate of Analysis Feb 28, 2023 P288352
D2311735 Certificate of Analysis Feb 28, 2023 P288352
D2311699 Certificate of Analysis Feb 28, 2023 P288352
D2311707 Certificate of Analysis Feb 28, 2023 P288352
D2311696 Certificate of Analysis Feb 28, 2023 P288352
D2311736 Certificate of Analysis Feb 28, 2023 P288352

Chemical and Physical Properties

Solubility Solvent:ethanol, Max Conc. mg/mL: 30.84, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 30.84, Max Conc. mM: 100
Molecular Weight 308.400 g/mol
XLogP3 3.300
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 5
Exact Mass 308.152 Da
Monoisotopic Mass 308.152 Da
Topological Polar Surface Area 54.100 Ų
Heavy Atom Count 23
Formal Charge 0
Complexity 395.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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