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Tyrene CR4 , Tyrosine-protein kinase JAK2 inhibitor, CAS No.1110670-40-0, Tyrosine-protein kinase JAK2 inhibitor

COA

Cas Number: 1110670-40-0
Molecular Weight: 320.34
PubChem CID: 9861871

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Item Number

T335809

Grouped product items
SKU	Size	Availability	Price	Qty
T335809-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$94.90
T335809-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$702.90

an inhibitor of JAK2 and Bcr-Abl (the fusion protein of Bcr and c-Abl)

Basic Description

Synonyms	UNII-T669M1395I \| 1110670-40-0 \| J-002517 \| N-benzyl-2-cyano-5-(3,4-dihydroxyphenyl)penta-2,4-dienamide \| Q27289723 \| (2E,4E)-N-benzyl-2-cyano-5-(3,4-dihydroxyphenyl)penta-2,4-dienamide \| LS-104 \| (E,E)-2-(Benzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acryl
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	INHIBITOR
Mechanism of action	Tyrosine-protein kinase JAK2 inhibitor
Product Description	Tyrene CR4 is a cell-permeable, reversible, and substrate competitive hydroxystryrylacrylonitrile tyrosine kinase inhibitor that show anti-tumor properties. Tyrene CR4 potently inhibits JAK2 and Bcr-Abl (the fusion protein of Bcr and c-Abl) (IC\|50\|~100-600 nM and 500-700 nM, respectively) by targeting their kinase activities. Tyrene CR4 displays excellent selectivity over other tyrosine kinases, Btk, Lck, Lyn, Src, Syk and ZAP-70 (IC\|50\|>5 μM). Tyrene CR4 has been shown to preferentially induce apoptosis in acute lymphoblastic (ALL) and myeloid leukemia cells (AML), while exhibiting little deleterious effect towards normal bone marrow cell differentiation and proliferation. Tyrene CR4 has also been reported to be more potent than AG 490 in inducing ALL cells growth arrest (IC\|50\|~ 120 nM vs. 5-25 μM).

Names and Identifiers

Smiles	C1=CC=C(C=C1)CNC(=O)C(=CC=CC2=CC(=C(C=C2)O)O)C#N
Isomeric SMILES	C1=CC=C(C=C1)CNC(=O)/C(=C/C=C/C2=CC(=C(C=C2)O)O)/C#N
PubChem CID	9861871
Molecular Weight	320.34

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO (10 mg/ml)
Molecular Weight	320.300 g/mol
XLogP3	3.100
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	320.116 Da
Monoisotopic Mass	320.116 Da
Topological Polar Surface Area	93.400 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	526.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	2
Covalently-Bonded Unit Count	1

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