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LPL Receptor
TY-52156 - ≥98%, high purity , CAS No.934369-14-9, Antagonist of S1P 3 receptor

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TY-52156 - ≥98%, high purity , CAS No.934369-14-9, Antagonist of S1P 3 receptor

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 934369-14-9
Molecular Weight: 364.27
PubChem CID: 16046248
PubChem SID: 504768012

In stock

Item Number

T275451

Grouped product items
SKU	Size	Availability	Price
T275451-5mg	5mg	3	$68.90
T275451-10mg	10mg	2	$107.90
T275451-25mg	25mg	2	$243.90
T275451-50mg	50mg	2	$375.90
T275451-100mg	100mg	2	$642.90

Novel S1P3 receptor antagonist

View related series

Class A GPCR (4138) GPCR/G Protein (3172) LPL Receptor (113) S1P3 receptor Antagonist (5)

Basic Description

Synonyms	N-(4-chloroanilino)-N'-(4-chlorophenyl)-3,3-dimethyl-2-oxobutanimidamide \| SCHEMBL16765243 \| SCHEMBL20927271 \| AKOS040742792 \| 1-(4-chlorophenylamino)-1-(4-chlorophenylhydrazono)-3,3-dimethyl-2-butanone \| E73429 \| N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobuta
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Novel S1P3 receptor antagonist (Ki = 110 nM). It preferentially inhibits the S1P-induced increase inintracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of S1P 3 receptor
Note	Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Shipped at 4°C. Store at -20°C long term. Store In the Dark. Product description： TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM。

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Phenylhydrazines

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Phenylhydrazines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylhydrazines
Alternative Parents	Chlorobenzenes Aryl chlorides Ketones Amidrazones Propargyl-type 1,3-dipolar organic compounds Amidines Organochlorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Phenylhydrazine - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Carboxylic acid amidrazone - Ketone - Amidine - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylhydrazines. These are compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent attached to a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

S1PR3 Tclin Sphingosine 1-phosphate receptor 3 (1 Activities)

Discover Target: S1PR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504768012
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504768012
IUPAC Name	N-(4-chloroanilino)-N'-(4-chlorophenyl)-3,3-dimethyl-2-oxobutanimidamide
INCHI	InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21-14-8-4-12(19)5-9-14)23-22-15-10-6-13(20)7-11-15/h4-11,22H,1-3H3,(H,21,23)
InChIKey	XONRRGIRSGNWFP-UHFFFAOYSA-N
Smiles	CC(C)(C)C(=O)C(=NC1=CC=C(C=C1)Cl)NNC2=CC=C(C=C2)Cl
Isomeric SMILES	CC(C)(C)C(=O)C(=NC1=CC=C(C=C1)Cl)NNC2=CC=C(C=C2)Cl
PubChem CID	16046248
Molecular Weight	364.27

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
C2515132	Certificate of Analysis	Mar 27, 2025	T275451
J2221748	Certificate of Analysis	Aug 21, 2023	T275451
J2221747	Certificate of Analysis	Aug 21, 2023	T275451
J2221746	Certificate of Analysis	Aug 21, 2023	T275451
J2221743	Certificate of Analysis	Aug 21, 2023	T275451
J2221738	Certificate of Analysis	Aug 21, 2023	T275451

Chemical and Physical Properties

Solubility	Soluble in DMSO to\xa075 mM and in\xa0Ethanol to\xa075 mM
Molecular Weight	364.300 g/mol
XLogP3	6.300
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	363.091 Da
Monoisotopic Mass	363.091 Da
Topological Polar Surface Area	53.500 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	446.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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