Skip to the beginning of the images gallery

TVB-2640 - 98%, high purity , CAS No.1399177-37-7

COA

Grade & Purity:

≥98%

Cas Number: 1399177-37-7
Molecular Weight: 439.55
PubChem CID: 66548316
PubChem SID: 488202053

In stock

Item Number

T414472

Grouped product items
SKU	Size	Availability	Price
T414472-5mg	5mg	5	$301.90
T414472-10mg	10mg	3	$395.90
T414472-25mg	25mg	2	$946.90
T414472-50mg	50mg	1	$1,137.90
T414472-100mg	100mg	1	$2,048.90

Fatty Acid Synthase Inhibitors

View related series

Fatty Acid Synthase (FASN) (41) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	Denifanstat \| 4-[1-[4-cyclobutyl-2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrile \| 1399177-37-7 \| FT-0654318 \| A937502 \| 4GF95B2LZA \| Denifanstat [INN] \| 3-(t-butoxycarbonylamino)propanoic acid \| BDBM137084 \| UNII-4GF95B2LZA
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information TVB-2640 TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis. Targets FAS

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzoyl derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzoyl derivatives
Intermediate Tree Nodes	Not available
Direct Parent	1-benzoylpiperidines
Alternative Parents	N-benzoylpiperidines Phenylpiperidines Phenyl-1,2,4-triazoles o-Toluamides Benzamides Benzonitriles Tertiary carboxylic acid amides Heteroaromatic compounds Tertiary amines Amino acids and derivatives Nitriles Azacyclic compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	1-benzoylpiperidine - N-benzoylpiperidine - Phenylpiperidine - Phenyltriazole - Phenyl-1,2,4-triazole - Benzamide - Benzoic acid or derivatives - O-toluamide - N-acyl-piperidine - Toluamide - Benzonitrile - Toluene - Piperidine - Tertiary carboxylic acid amide - Azole - Heteroaromatic compound - Triazole - 1,2,4-triazole - Amino acid or derivatives - Carboxamide group - Tertiary amine - Nitrile - Carbonitrile - Azacycle - Carboxylic acid derivative - Organoheterocyclic compound - Organonitrogen compound - Hydrocarbon derivative - Amine - Organic oxide - Cyanide - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 1-benzoylpiperidines. These are compounds containing a piperidine ring substituted at the 1-position with a benzoyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	4.638
HBD Count	1
Rotatable Bond	4

Associated Targets(Human)

FASN Tchem Fatty acid synthase (2 Activities)

Discover Target: FASN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488202053
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202053
IUPAC Name	4-[1-[4-cyclobutyl-2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrile
INCHI	InChI=1S/C27H29N5O/c1-17-14-24(22-4-3-5-22)25(26-29-18(2)30-31-26)15-23(17)27(33)32-12-10-21(11-13-32)20-8-6-19(16-28)7-9-20/h6-9,14-15,21-22H,3-5,10-13H2,1-2H3,(H,29,30,31)
InChIKey	BBGOSBDSLYHMRA-UHFFFAOYSA-N
Smiles	CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NNC(=N4)C)C5CCC5
Isomeric SMILES	CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NNC(=N4)C)C5CCC5
PubChem CID	66548316
Molecular Weight	439.55

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number	Certificate Type	Date	Item
J2314340	Certificate of Analysis	Sep 21, 2023	T414472
J2314341	Certificate of Analysis	Sep 21, 2023	T414472
J2314339	Certificate of Analysis	Sep 21, 2023	T414472
J2314338	Certificate of Analysis	Sep 21, 2023	T414472
J2314342	Certificate of Analysis	Sep 21, 2023	T414472
D2326344	Certificate of Analysis	Mar 29, 2023	T414472
D2326356	Certificate of Analysis	Mar 29, 2023	T414472
D2326346	Certificate of Analysis	Mar 29, 2023	T414472
D2326351	Certificate of Analysis	Mar 29, 2023	T414472
D2326355	Certificate of Analysis	Mar 29, 2023	T414472
D2326359	Certificate of Analysis	Mar 29, 2023	T414472
D2326352	Certificate of Analysis	Mar 29, 2023	T414472
D2326345	Certificate of Analysis	Mar 29, 2023	T414472
D2326342	Certificate of Analysis	Mar 29, 2023	T414472
D2326347	Certificate of Analysis	Mar 29, 2023	T414472

Show more⌵

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 88 mg/mL (200.2 mM); Ethanol: 88 mg/mL (200.2 mM); Water: Insoluble;
Sensitivity	Light sensitive
DMSO(mg / mL) Max Solubility	88
DMSO(mM) Max Solubility	200.204754862928
Water(mg / mL) Max Solubility	＜1
Molecular Weight	439.600 g/mol
XLogP3	5.300
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	439.237 Da
Monoisotopic Mass	439.237 Da
Topological Polar Surface Area	85.700 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	728.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Alternative Products

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration