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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab183313-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$159.90
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Ab183313-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$759.90
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Ab183313-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,699.90
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Ab183313-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,999.90
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Purity>90% (SDS-PAGE&SEC); Endotoxin Level<0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Conjugated (MC-GGFG-DXd)
| Product Name | Trastuzumab deruxtecan (anti-ERBB2) - Primary antibody, specific to ERBB2, >90% (SDS-PAGE&SEC), high purity, Human IgG1, BINDING AGENT of Receptor protein-tyrosine kinase erbB-2 binding agent |
|---|---|
| Synonyms | Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody | C erb B2/neu protein antibody | CD340 antibody | CD340 antigen antibody | Cerb B2/neu protein antibody | CerbB2 antibody | Erb b2 receptor tyr |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC) |
| Biochemical and Physiological Mechanisms | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a |
| Host species | Human |
| Specificity | ERBB2 |
| Positive Control | Lot by Lot |
| Conjugation | MC-GGFG-DXd |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | BINDING AGENT |
| Mechanism of action | BINDING AGENT of Receptor protein-tyrosine kinase erbB-2 binding agent |
| Product Description |
Trastuzumab deruxtecan (anti-ERBB2) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan (anti-ERBB2) is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd). Trastuzumab deruxtecan (anti-ERBB2) can be used for the research of HER2-positive breast cancer and gastric cancer. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 153.75 kDa |
| Purification Method | Protein A purified |
| Purity | >90% (SDS-PAGE&SEC) |
| Shape | Liquid |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1826843-81-5 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Trastuzumab deruxtecan (anti-ERBB2) (Ab183313) - Flow Cytometry
Flow Cytometry analysis of MCF7 cells labelling ERBB2 (red) with Trastuzumab deruxtecan (anti-ERBB2) (Ab183313) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Trastuzumab deruxtecan (anti-ERBB2) (Ab183313) - ELISA
Immobilized Recombinant Human ErbB2/HER2 protein (rp169607) at 1.0 μg/mL can bind Trastuzumab deruxtecan (anti-ERBB2) (Ab183313) with the EC₅₀ of 58.19 ng/mL.
Trastuzumab deruxtecan (anti-ERBB2) (Ab183313) - SEC
The purity of Trastuzumab deruxtecan (anti-ERBB2) (Ab183313) is more than 95% verified by HPLC.