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Torcetrapib - ≥98%, high purity , Cholesteryl ester transfer protein inhibitor, CAS No.262352-17-0, Cholesteryl ester transfer protein inhibitor

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
E129832
Grouped product items
SKU Size
Availability
 Price Qty
E129832-5mg
5mg
3
$103.90
E129832-10mg
10mg
3
$128.90
E129832-50mg
50mg
3
$493.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Inhibitor of cholesteryl ester transfer protein (CETP)

View related series
CETP (8) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms BRD-K55675242-001-03-0 | )-carboxylate | N-2790 | CP-529414 | s2792 | TORCETRAPIB [MI] | AMY24146 | 1(2H)-Quinolinecarboxylic acid, 4-(((3,5-bis(trifluoromethyl)phenyl)methyl) (methoxycarbonyl)amino)-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl es
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial functionin vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.
Legal Information Sold for only research purposes
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type INHIBITOR
Mechanism of action Cholesteryl ester transfer protein inhibitor
Product Description

Torcetrapib is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma. Phase 3.
A CETP inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Quinolines and derivatives
Subclass Hydroquinolines
Intermediate Tree Nodes Not available
Direct Parent Hydroquinolines
Alternative Parents Trifluoromethylbenzenes  Methylcarbamates  Organic carbonic acids and derivatives  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organofluorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  Alkyl fluorides  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Tetrahydroquinoline - Trifluoromethylbenzene - Monocyclic benzene moiety - Benzenoid - Methylcarbamate - Carbamic acid ester - Carbonic acid derivative - Azacycle - Alkyl fluoride - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Alkyl halide - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as hydroquinolines. These are derivatives of quinoline in which in which at least one double bond in the quinoline moiety are reduced by adding two hydrogen atoms.
External Descriptors carbamate ester - quinolines - (trifluoromethyl)benzenes

Associated Targets(Human)

CETP Tchem Cholesteryl ester transfer protein (10 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
LPL Tchem Lipoprotein lipase (101 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CETP Tchem Cholesteryl ester transfer protein (2422 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LIPC Tchem Hepatic lipase (436 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MTTP Tclin Microsomal triglyceride transfer protein large subunit (242 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H295R (47 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LIPG Tchem Endothelial lipase (1021 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PLTP Tbio Phospholipid transfer protein (94 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LCAT Tchem Phosphatidylcholine-sterol acyltransferase (155 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cynomolgus monkey (4946 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hamster (598 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504757441
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504757441
IUPAC Name ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
INCHI InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1
InChIKey CMSGWTNRGKRWGS-NQIIRXRSSA-N
Smiles CCC1CC(C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)OC
Isomeric SMILES CC[C@@H]1C[C@@H](C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)OC
WGK Germany 3
Molecular Weight 600.47
Reaxy-Rn 13697133
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13697133&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
A2213330 Certificate of Analysis Oct 20, 2023 E129832
A2213333 Certificate of Analysis Oct 20, 2023 E129832
H1504073 Certificate of Analysis Mar 15, 2023 E129832

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 30.02, Max Conc. mM: 50
Molecular Weight 600.500 g/mol
XLogP3 7.000
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 13
Rotatable Bond Count 7
Exact Mass 600.167 Da
Monoisotopic Mass 600.167 Da
Topological Polar Surface Area 59.100 Ų
Heavy Atom Count 41
Formal Charge 0
Complexity 889.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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