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TL 12-186 - ≥98%(HPLC), high purity , CAS No.2250025-88-6, cereblon

COA

Grade & Purity:

Moligand™

≥98%(HPLC)

Cas Number: 2250025-88-6
Molecular Weight: 931.46
PubChem CID: 134812843

In stock

Item Number

T288251

Grouped product items
SKU	Size	Availability	Price
T288251-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$98.90
T288251-5mg	5mg	3	$345.90
T288251-10mg	10mg	2	$583.90
T288251-25mg	25mg	2	$1,088.90
T288251-50mg	50mg	2	$1,741.90

Multikinase degrading PROTAC

View related series

CDK (252) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) cereblon (14) Hydroxy PEG (472) Lipid PEG (395) PROTAC (2077) PROTAC linker (720) PROTAC Linkers (1898) PROTACs (183) Tetrazine-PEG (145)

Basic Description

Synonyms	N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	PROTAC®comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand,pomalidomide. Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines.Negative controlTL 13-27 is also available.PROTAC®is a registered tr
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Mechanism of action	cereblon

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazinanes
    - Subclass Piperazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazinanes
Subclass	Piperazines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpiperazines
Alternative Parents	N-arylpiperazines Alpha amino acid amides Phthalimides Isoindoles Benzenesulfonyl compounds Piperidinediones Dialkylarylamines Aniline and substituted anilines Secondary alkylarylamines N-alkylpiperazines Halopyrimidines Delta lactams Aminopyrimidines and derivatives N-substituted carboxylic acid imides Imidolactams Aryl chlorides Vinylogous amides Sulfones N-unsubstituted carboxylic acid imides Heteroaromatic compounds Dicarboximides Trialkylamines Secondary carboxylic acid amides Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-arylpiperazine - Phenylpiperazine - Alpha-amino acid amide - Phthalimide - Isoindolone - Alpha-amino acid or derivatives - N-substituted-alpha-amino acid - Benzenesulfonyl group - Isoindole or derivatives - Isoindole - Isoindoline - Aniline or substituted anilines - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Piperidinedione - N-alkylpiperazine - Secondary aliphatic/aromatic amine - Piperidinone - Halopyrimidine - Delta-lactam - Aminopyrimidine - Imidolactam - Benzenoid - Pyrimidine - Piperidine - Carboxylic acid imide, n-substituted - Monocyclic benzene moiety - Aryl halide - Aryl chloride - Heteroaromatic compound - Vinylogous amide - Sulfonyl - Sulfone - Carboxylic acid imide, n-unsubstituted - Dicarboximide - Carboxylic acid imide - Tertiary aliphatic amine - Tertiary amine - Secondary carboxylic acid amide - Lactam - Carboxamide group - Amino acid or derivatives - Azacycle - Secondary amine - Ether - Dialkyl ether - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Carbonyl group - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CRBN Tclin Protein cereblon (0 Activities)

Discover Target: CRBN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[2-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetamide
INCHI	InChI=1S/C44H51ClN10O9S/c1-28(2)65(61,62)36-9-4-3-7-33(36)50-40-32(45)26-48-44(52-40)49-29-10-12-30(13-11-29)54-19-17-53(18-20-54)21-23-64-25-24-63-22-16-46-38(57)27-47-34-8-5-6-31-39(34)43(60)55(42(31)59)35-14-15-37(56)51-41(35)58/h3-13,26,28,35,47H,14-25,27H2,1-2H3,(H,46,57)(H,51,56,58)(H2,48,49,50,52)
InChIKey	YNGWQHGVASHCBK-UHFFFAOYSA-N
Smiles	CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3)N4CCN(CC4)CCOCCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O
PubChem CID	134812843
Molecular Weight	931.46

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
E2324500	Certificate of Analysis	Apr 14, 2023	T288251
E2324496	Certificate of Analysis	Apr 14, 2023	T288251
E2324486	Certificate of Analysis	Apr 14, 2023	T288251
E2324502	Certificate of Analysis	Apr 14, 2023	T288251

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 93.15, Max Conc. mM: 100
Sensitivity	Moisture & Light sensitive
Molecular Weight	931.500 g/mol
XLogP3	4.600
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	20
Exact Mass	930.325 Da
Monoisotopic Mass	930.325 Da
Topological Polar Surface Area	242.000 Å²
Heavy Atom Count	65
Formal Charge	0
Complexity	1740.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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