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Tiplaxtinin - ≥98%(HPLC), high purity , CAS No.393105-53-8

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
T287897
Grouped product items
SKU Size
Availability
 Price Qty
T287897-10mg
10mg
2
$225.90
T287897-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$825.90
T287897-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$3,717.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

View related series
Amino Acid/Protein Metabolism (1836) Apoptosis (4276) Metabolic Enzyme/Protease (4860) PAI-1 (26)

Basic Description

Synonyms PAI-039 | WAY-168039 | 2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxoacetic acid | FT-0700303 | HY-15253 | Tiplasinin [USAN:INN] | A14190 | Tiplasinin (USAN) | 2-[1-benzyl-5-[4-(triluoromethoxy)phenyl]indol-3-yl]-2-oxoacetic acid | CHEBI:1777
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50= 2.7μM). Induces vascular smooth muscle cell apoptosisin vitroand reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute ar
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Indoles and derivatives
Subclass Indolyl carboxylic acids and derivatives
Intermediate Tree Nodes Not available
Direct Parent Indole-3-acetic acid derivatives
Alternative Parents N-alkylindoles  Indoles  Phenoxy compounds  Phenol ethers  Aryl ketones  Substituted pyrroles  Alpha-keto acids and derivatives  Vinylogous amides  Alpha-hydroxy ketones  Heteroaromatic compounds  Trihalomethanes  Azacyclic compounds  Carboxylic acids  Monocarboxylic acids and derivatives  Alkyl fluorides  Organic oxides  Organonitrogen compounds  Organofluorides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Indole-3-acetic acid derivative - N-alkylindole - Indole - Phenol ether - Phenoxy compound - Aryl ketone - Alpha-keto acid - Substituted pyrrole - Benzenoid - Keto acid - Monocyclic benzene moiety - Alpha-hydroxy ketone - Vinylogous amide - Heteroaromatic compound - Pyrrole - Ketone - Trihalomethane - Carboxylic acid derivative - Carboxylic acid - Azacycle - Monocarboxylic acid or derivatives - Organooxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Halomethane - Alkyl halide - Alkyl fluoride - Carbonyl group - Organic oxide - Organic oxygen compound - Organohalogen compound - Organofluoride - Organonitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as indole-3-acetic acid derivatives. These are compounds containing an acetic acid (or a derivative) linked to the C3 carbon atom of an indole.
External Descriptors Not available

Associated Targets(Human)

SERPINE1 Tchem Plasminogen activator inhibitor-1 (498 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterococcus faecium (13803 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Canis familiaris (36305 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ftsZ Cell division protein FtsZ (54 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504764206
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764206
IUPAC Name 2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxoacetic acid
INCHI InChI=1S/C24H16F3NO4/c25-24(26,27)32-18-9-6-16(7-10-18)17-8-11-21-19(12-17)20(22(29)23(30)31)14-28(21)13-15-4-2-1-3-5-15/h1-12,14H,13H2,(H,30,31)
InChIKey ODXQFEWQSHNQNI-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)CN2C=C(C3=C2C=CC(=C3)C4=CC=C(C=C4)OC(F)(F)F)C(=O)C(=O)O
Isomeric SMILES C1=CC=C(C=C1)CN2C=C(C3=C2C=CC(=C3)C4=CC=C(C=C4)OC(F)(F)F)C(=O)C(=O)O
PubChem CID 6450819
Molecular Weight 439.38

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
J2116097 Certificate of Analysis Jul 08, 2024 T287897
J2116098 Certificate of Analysis Jul 08, 2024 T287897
J2116099 Certificate of Analysis Jul 08, 2024 T287897

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 43.94, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 43.94, Max Conc. mM: 100
Molecular Weight 439.400 g/mol
XLogP3 5.800
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 6
Exact Mass 439.103 Da
Monoisotopic Mass 439.103 Da
Topological Polar Surface Area 68.500 Ų
Heavy Atom Count 32
Formal Charge 0
Complexity 671.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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