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THK5351 - 98%, high purity , Diagnostic, CAS No.1707147-26-9, Diagnostic

COA

Grade & Purity:

≥98%

Cas Number: 1707147-26-9
Molecular Weight: 327.35
PubChem CID: 91936858

In stock

Item Number

T646216

Grouped product items
SKU	Size	Availability	Price
T646216-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$151.90
T646216-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$452.90
T646216-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$653.90
T646216-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,206.90
T646216-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,911.90

View related series

Neuronal Signaling (3320) Tau Protein (15)

Basic Description

Synonyms	CS-6887 \| J3.349.111E \| Q27281465 \| UNII-JE3F6WUN31 \| 2-(6-Methylaminopyridine-3-yl)-6-((S)-3-fluoro-2-hydroxy-propyloxy)quinoline \| MS-24888 \| 2-Propanol, 1-fluoro-3-((2-(6-(methylamino)-3-pyridinyl)-6-quinolinyl)oxy)-, (2S)- \| HY-101183 \| SCHEMBL1682918
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action	Diagnostic
Product Description	THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain. In Vitro Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). 18 F-THK5351 binds to Alzheimer disease hippocampal homogenates with high affinity (K d =2.9 nM; maximum number of binding sites=368.3 pmol/g tissue). It has fast dissociation from white-matter tissue. The THK5351 binding amount correlates with the amount of tau deposits in tissue. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo THK5351 exhibits favorable pharmacokinetics and no defluorination in mice. 18 F-THK5351 enters the brain immediately after intravenous injection and shows a fast washout from the brain. At 0.1 and 1 mg/kg, no animals died and no treatment-related changes in any animal are noted in clinical observations, body weight measurement, and pathologic examination . Autoradiography in the brain sections of patients with PSP demonstrates [ 3 H]THK-5351 binding to tau deposits with a high selectivity. Although patients with PSP exhibits no remarkable [ 18 F]THK-5351 retention in the temporal cortex, significantly higher tracer retention is observed in the globus pallidus and midbrain. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Bipyridines and oligopyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Bipyridines and oligopyridines
Intermediate Tree Nodes	Not available
Direct Parent	Bipyridines and oligopyridines
Alternative Parents	Quinolines and derivatives Phenol ethers Aminopyridines and derivatives Alkyl aryl ethers Imidolactams Heteroaromatic compounds Secondary alcohols Fluorohydrins Azacyclic compounds Organofluorides Hydrocarbon derivatives Amines Alkyl fluorides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Bipyridine - Quinoline - Phenol ether - Alkyl aryl ether - Aminopyridine - Imidolactam - Benzenoid - Heteroaromatic compound - Secondary alcohol - Fluorohydrin - Halohydrin - Azacycle - Ether - Alcohol - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Amine - Alkyl halide - Alkyl fluoride - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as bipyridines and oligopyridines. These are organic compounds containing two pyridine rings linked to each other.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S)-1-fluoro-3-[2-[6-(methylamino)pyridin-3-yl]quinolin-6-yl]oxypropan-2-ol
INCHI	InChI=1S/C18H18FN3O2/c1-20-18-7-3-13(10-21-18)17-5-2-12-8-15(4-6-16(12)22-17)24-11-14(23)9-19/h2-8,10,14,23H,9,11H2,1H3,(H,20,21)/t14-/m1/s1
InChIKey	DLVXFZWSPCOWSN-CQSZACIVSA-N
Smiles	CNC1=NC=C(C=C1)C2=NC3=C(C=C2)C=C(C=C3)OCC(CF)O
Isomeric SMILES	CNC1=NC=C(C=C1)C2=NC3=C(C=C2)C=C(C=C3)OC[C@@H](CF)O
Alternate CAS	1707147-26-9
PubChem CID	91936858
MeSH Entry Terms	18F-THK5351;THK5351
Molecular Weight	327.35

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 50 mg/mL (152.74 mM; Need ultrasonic)
Molecular Weight	327.400 g/mol
XLogP3	2.800
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	327.138 Da
Monoisotopic Mass	327.138 Da
Topological Polar Surface Area	67.300 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	387.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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