Skip to the beginning of the images gallery

Thiazovivin - ≥99%, high purity , CAS No.1226056-71-8

COA

Grade & Purity:

≥99%

Cas Number: 1226056-71-8
Molecular Weight: 311.36
PubChem CID: 46209426
PubChem SID: 504770684

In stock

Item Number

T126478

Grouped product items
SKU	Size	Availability	Price
T126478-5mg	5mg	2	$86.90
T126478-10mg	10mg	2	$151.90
T126478-25mg	25mg	2	$342.90
T126478-50mg	50mg	2	$532.90
T126478-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$791.90

Rho kinase inhibitor

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Cytoskeleton (498) ROCK (71) Stem Cell/Wnt (1019) TGF-beta/Smad (303)

Basic Description

Synonyms	HB3240 \| s1459 \| C15H13N5OS \| CCG-267592 \| J-004834 \| CS-0468 \| NCGC00187983-10 \| Thiazovivin (GMP) \| 1226056-71-8 \| HY-13257G \| SCHEMBL669856 \| MLS006011152 \| CS-0626100 \| MFCD16495823 \| SMR004702926 \| AC-28391 \| 4-THIAZOLECARBOXAMIDE, N-(PHENYLMETHYL)-2
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Thiazovivin is a compound which dramatically improves the survival of hESCs upon trypsinization. In combination with ALK5 (TGFβ receptor) inhibitor SB-431542 and MEK inhibitor PD-0325901, thiazovivin promotes the transformation of fibroblasts into st
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Thiazovivin is a new type of ROCK inhibitor with an IC50 of 0.5 μM in a cell-free assay, which promotes the survival of human embryonic stem cells (hESC) after single cell isolation.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azoles
    - Subclass Thiazoles
      - Level5 Thiazolecarboxylic acids and derivatives
        Level6 Thiazolecarboxamides

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azoles
Subclass	Thiazoles
Intermediate Tree Nodes	Thiazolecarboxylic acids and derivatives
Direct Parent	Thiazolecarboxamides
Alternative Parents	2-heteroaryl carboxamides Aminopyrimidines and derivatives 2,4-disubstituted thiazoles Imidolactams Benzene and substituted derivatives 2-amino-1,3-thiazoles Heteroaromatic compounds Secondary carboxylic acid amides Amino acids and derivatives Secondary amines Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-heteroaryl carboxamide - Thiazolecarboxamide - 2,4-disubstituted 1,3-thiazole - Aminopyrimidine - Monocyclic benzene moiety - Pyrimidine - Benzenoid - 1,3-thiazol-2-amine - Imidolactam - Heteroaromatic compound - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Secondary amine - Carboxylic acid derivative - Azacycle - Organic oxide - Organooxygen compound - Organonitrogen compound - Amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as thiazolecarboxamides. These are heterocyclic compounds containing a thiazole ring which bears a carboxylic acid amide group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770684
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770684
IUPAC Name	N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
INCHI	InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
InChIKey	DOBKQCZBPPCLEG-UHFFFAOYSA-N
Smiles	C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
Isomeric SMILES	C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
WGK Germany	3
Molecular Weight	311.36

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
I2117486	Certificate of Analysis	Jul 07, 2023	T126478
I2117487	Certificate of Analysis	Jul 07, 2023	T126478
I2117484	Certificate of Analysis	Jul 07, 2023	T126478
I2117485	Certificate of Analysis	Jul 07, 2023	T126478
I2117488	Certificate of Analysis	Jul 07, 2023	T126478

Chemical and Physical Properties

Solubility	DMSO 15 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Molecular Weight	311.400 g/mol
XLogP3	2.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	311.084 Da
Monoisotopic Mass	311.084 Da
Topological Polar Surface Area	108.000 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	364.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration