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TH287 - >98%, high purity , CAS No.1609960-30-6

COA

Grade & Purity:

≥98%

Cas Number: 1609960-30-6
Molecular Weight: 269.13
PubChem CID: 73441664
PubChem SID: 504772332

In stock

Item Number

T305079

Grouped product items
SKU	Size	Availability	Price
T305079-5mg	5mg	2	$81.90
T305079-10mg	10mg	2	$122.90
T305079-25mg	25mg	2	$276.90
T305079-50mg	50mg	2	$484.90
T305079-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$870.90
T305079-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,959.90

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) DNA/RNA Synthesis (362)

Basic Description

Synonyms	SCHEMBL15757374 \| (S)-N-(6-chloro-5-(2-(5-(2-fluoro-4-methylphenyl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2?,3?:2,3]imidazo[4,5-c]pyridin-6(5H)-yl)- 2-oxoethoxy)pyridin-2-yl)methanesulfonamide \| UNII-R6DCB5MSM2 \| TH287 \| TH-287 \| CCG-267139 \| Q27452986
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	TH287 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 0.8 nM. MTH1 hydrolyzes oxidized purine nucleoside triphosphates that might otherwise be incorporated into DNA/RNA and contribute to DNA damage.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazines
    - Subclass Pyrimidines and pyrimidine derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazines
Subclass	Pyrimidines and pyrimidine derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpyrimidines
Alternative Parents	Dichlorobenzenes Aminopyrimidines and derivatives Imidolactams Aryl chlorides Heteroaromatic compounds Azacyclic compounds Primary amines Organochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	4-phenylpyrimidine - 1,2-dichlorobenzene - Aminopyrimidine - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Imidolactam - Benzenoid - Heteroaromatic compound - Azacycle - Organohalogen compound - Hydrocarbon derivative - Organochloride - Organonitrogen compound - Amine - Primary amine - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpyrimidines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrimidine ring through a CC or CN bond. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

NUDT1 Tchem 7,8-dihydro-8-oxoguanine triphosphatase (7 Activities)

Discover Target: NUDT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MRC5 (9203 Activities)

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MT4 (17854 Activities)

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NCI-H358 (882 Activities)

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SW480 (6023 Activities)

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U2OS (164939 Activities)

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A549 (127892 Activities)

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BJ (6930 Activities)

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HMEC (560 Activities)

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NCI-H460 (60772 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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Associated Targets(non-human)

MDCK (10148 Activities)

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Liver microsome (341 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504772332
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772332
IUPAC Name	6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine
INCHI	InChI=1S/C11H10Cl2N4/c1-15-9-5-8(16-11(14)17-9)6-3-2-4-7(12)10(6)13/h2-5H,1H3,(H3,14,15,16,17)
InChIKey	URWCXPXBBITYLR-UHFFFAOYSA-N
Smiles	CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N
Isomeric SMILES	CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N
PubChem CID	73441664
Molecular Weight	269.13

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
A2219745	Certificate of Analysis	Nov 04, 2024	T305079
A2219597	Certificate of Analysis	Nov 04, 2024	T305079
A2219746	Certificate of Analysis	Nov 04, 2024	T305079
A2219744	Certificate of Analysis	Nov 04, 2024	T305079
A2219706	Certificate of Analysis	Nov 04, 2024	T305079
A2219708	Certificate of Analysis	Nov 04, 2024	T305079

Chemical and Physical Properties

Solubility	5 mg/mL, clear (warmed)
Molecular Weight	269.130 g/mol
XLogP3	3.100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	268.028 Da
Monoisotopic Mass	268.028 Da
Topological Polar Surface Area	63.800 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	254.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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TH287 - >98%, high purity , CAS No.1609960-30-6

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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