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Tenalisib R Enantiomer - 98%, high purity , CAS No.1639417-54-1

COA

Grade & Purity:

≥98%

Cas Number: 1639417-54-1
Molecular Weight: 415.42
PubChem CID: 117729511

In stock

Item Number

T650565

Grouped product items
SKU	Size	Availability	Price
T650565-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$190.90
T650565-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$390.90
T650565-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$590.90
T650565-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$890.90
T650565-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,500.90
T650565-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,200.90

View related series

PI3K (243) PI3K/Akt/mTOR (765)

Basic Description

Synonyms	1639417-54-1 \| HY-112172 \| MS-27201 \| SCHEMBL16279824 \| DTXSID001138191 \| AKOS040740197 \| RP6530 R Enantiomer \| 3-(3-Fluorophenyl)-2-[(1R)-1-(9H-purin-6-ylamino)propyl]-4H-1-benzopyran-4-one \| CS-0043601 \| BT166452 \| Tenalisib R Enantiomer \| 3-(3-fluoroph
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Tenalisib R Enantiomer (RP6530 R Enantiomer) is an R enantiomer of Tenalisib. Tenalisib is a potent and selective PI3Kδ and PI3Kγ inhibitor with IC 50 values of 25 and 33 nM, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Tenalisib R Enantiomer (RP6530 R Enantiomer) is an R enantiomer of Tenalisib. Tenalisib is a potent and selective PI3Kδ and PI3Kγ inhibitor with IC 50 values of 25 and 33 nM, respectively. In Vitro Tenalisib, a dual PI3K δ/γ inhibitor, potentiates Ruxolitinib activity in the JAK2-V617F mutant erythroleukemia cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Isoflavonoids
    - Subclass Isoflav-2-enes

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Isoflavonoids
Subclass	Isoflav-2-enes
Intermediate Tree Nodes	Not available
Direct Parent	Isoflavones
Alternative Parents	Chromones Imidazopyrimidines Secondary alkylarylamines Fluorobenzenes Dihydropyranones Pyrimidines and pyrimidine derivatives Imidolactams Alpha-branched alpha,beta-unsaturated ketones Imidazolines Imidazoles Heteroaromatic compounds Enones Acryloyl compounds Ketones Vinyl fluorides Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Formamidines Fluoroalkenes Dialkylamines Carboximidamides Azacyclic compounds Organopnictogen compounds Organofluorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Isoflavone - Chromone - 1-benzopyran - Benzopyran - Imidazopyrimidine - Secondary aliphatic/aromatic amine - Pyranone - Halobenzene - Fluorobenzene - Dihydropyranone - Imidolactam - Alpha-branched alpha,beta-unsaturated-ketone - Benzenoid - Pyrimidine - Pyran - Monocyclic benzene moiety - Heteroaromatic compound - Alpha,beta-unsaturated ketone - 2-imidazoline - Imidazole - Enone - Azole - Acryloyl-group - Ketone - Formamidine - Oxacycle - Azacycle - Fluoroalkene - Haloalkene - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Vinyl halide - Vinyl fluoride - Secondary amine - Secondary aliphatic amine - Amidine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as isoflavones. These are polycyclic compounds containing a 2-isoflavene skeleton which bears a ketone group at the C4 carbon atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	3-(3-fluorophenyl)-2-[(1R)-1-(7H-purin-6-ylamino)propyl]chromen-4-one
INCHI	InChI=1S/C23H18FN5O2/c1-2-16(29-23-19-22(26-11-25-19)27-12-28-23)21-18(13-6-5-7-14(24)10-13)20(30)15-8-3-4-9-17(15)31-21/h3-12,16H,2H2,1H3,(H2,25,26,27,28,29)/t16-/m1/s1
InChIKey	HDXDQPRPFRKGKZ-MRXNPFEDSA-N
Smiles	CCC(C1=C(C(=O)C2=CC=CC=C2O1)C3=CC(=CC=C3)F)NC4=NC=NC5=C4NC=N5
Isomeric SMILES	CC[C@H](C1=C(C(=O)C2=CC=CC=C2O1)C3=CC(=CC=C3)F)NC4=NC=NC5=C4NC=N5
PubChem CID	117729511
Molecular Weight	415.42

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (240.72 mM; Need ultrasonic)
Molecular Weight	415.400 g/mol
XLogP3	4.200
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	415.144 Da
Monoisotopic Mass	415.144 Da
Topological Polar Surface Area	92.800 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	703.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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