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TCID - 10mM in DMSO, high purity , CAS No.30675-13-9, Inhibitor of ubiquitin C-terminal hydrolase L3
Potent and selective ubiquitin C-terminal hydrolase-L3 inhibitor
Basic Description
Synonyms
30675-13-9 | TCID | 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione | 4,5,6,7-Tetrachloroindan-1,3-dione | UCH-L3 Inhibitor | 4,5,6,7-tetrachloroindene-1,3-dione | 4,5,6,7-Tetrachloroindane-1,3-dione | 1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro- | CHEMBL1241028 | compound 6
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
TCID is a cell penetrant potent and specific inhibitor of UCH-L3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3). TCID is used to distinguish between UCH-L1 and UCH-L3 activities in cells.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of ubiquitin C-terminal hydrolase L3
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Benzenoids
Class
Indanes
Subclass
Indanones
Intermediate Tree Nodes
Not available
Direct Parent
Indanediones
Alternative Parents
Aryl alkyl ketones Beta-diketones Aryl chlorides Vinylogous halides Organochlorides Organic oxides Hydrocarbon derivatives
Molecular Framework
Aromatic homopolycyclic compounds
Substituents
Indanedione - Aryl ketone - Aryl alkyl ketone - 1,3-diketone - Aryl chloride - Aryl halide - 1,3-dicarbonyl compound - Vinylogous halide - Ketone - Organooxygen compound - Organochloride - Organohalogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic homopolycyclic compound
Description
This compound belongs to the class of organic compounds known as indanediones. These are compounds containing an indane ring bearing two ketone groups.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
4,5,6,7-tetrachloroindene-1,3-dione
INCHI
InChI=1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2
InChIKey
IDLAOWFFKWRNHB-UHFFFAOYSA-N
Smiles
C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
Isomeric SMILES
C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
PubChem CID
2729042
Molecular Weight
283.92
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Molecular Weight
283.900 g/mol
XLogP3
3.900
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
0
Exact Mass
283.878 Da
Monoisotopic Mass
281.881 Da
Topological Polar Surface Area
34.100 Ų
Heavy Atom Count
15
Formal Charge
0
Complexity
289.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Shaowei Bo, Dong Zhang, Mengjie Ma, Xukai Mo, Julia Stabinska, Michael T. McMahon, Changzheng Shi, Liangping Luo.
(2023)
Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents. Pharmaceuticals,
16
(5):
(639).
2.
Wang Qian, He Yuan, Lu Rui, Wang Wen-Ming, Yang Ke-Wu, Fan Hai Ming, Jin Yi, Blackburn G. Michael.
(2018)
Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids. BIOSCIENCE REPORTS,
38
(2):
3.
Guiying Zhu, Chaozheng Liu, Changli Zhang, Jiangtao Shi, Changtong Mei, Mingzhu Pan, Zhipeng Liu.
(2024)
Activating the Room-Temperature Phosphorescence of Organic Dyes through the Confinement Effect of Delignified Wood. ACS Sustainable Chemistry & Engineering,
12
(9):
(3726-3735).
4.
Binhao Wang, Yu Shen, Ruonan Hao, Shuheng Pan, Ruizhi Han, Ye Ni.
(2025)
Novel Approach for Efficient Separation of Primary Amines Using Supercritical Fluid Chromatography. CHIRALITY,
37
(1):
(e70012).
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4 Citations