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TCID - 97%, high purity , CAS No.30675-13-9, Inhibitor of ubiquitin C-terminal hydrolase L3

4 Citations

COA

Grade & Purity:

Moligand™

≥97%

Cas Number: 30675-13-9
Molecular Weight: 283.92
PubChem CID: 2729042
PubChem SID: 504760957

In stock

Item Number

T169439

Grouped product items
SKU	Size	Availability	Price
T169439-1mg	1mg	2	$28.90
T169439-5mg	5mg	1	$63.90
T169439-25mg	25mg	1	$233.90
T169439-100mg	100mg	1	$842.90

Potent and selective ubiquitin C-terminal hydrolase-L3 inhibitor

View related series

Cell Cycle/DNA Damage (2602) Deubiquitinase (86) ubiquitin C-terminal hydrolase L3 Inhibitor (1) Unfolded Protein Response (214)

Basic Description

Synonyms	4,5,6,7-Tetrachloroindane-1,3-dione \| C9H2Cl4O2 \| Maybridge1_006552 \| GTPL8660 \| HMS3653C11 \| HMS560B18 \| UCH 23;UCH23;UCH-23;UCH-L3 Inhibitor;4,5,6,7-tetrachloroindan-1,3-dione \| UCH-L3 \| UCH-L3 Inhibitor \| 4,5,6,7-Tetrachloro indane-1,3-dione \| HY-18638
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	TCID is a cell penetrant potent and specific inhibitor of UCH-L3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3). TCID is used to distinguish between UCH-L1 and UCH-L3 activities in cells.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ubiquitin C-terminal hydrolase L3
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Indanes
    - Subclass Indanones

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Indanes
Subclass	Indanones
Intermediate Tree Nodes	Not available
Direct Parent	Indanediones
Alternative Parents	Aryl alkyl ketones Beta-diketones Aryl chlorides Vinylogous halides Organochlorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	Indanedione - Aryl ketone - Aryl alkyl ketone - 1,3-diketone - Aryl chloride - Aryl halide - 1,3-dicarbonyl compound - Vinylogous halide - Ketone - Organooxygen compound - Organochloride - Organohalogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as indanediones. These are compounds containing an indane ring bearing two ketone groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (2 Activities)

Discover Target: UCHL3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UCHL1 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L1 (107 Activities)

Discover Target: UCHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (50 Activities)

Discover Target: UCHL3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504760957
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504760957
IUPAC Name	4,5,6,7-tetrachloroindene-1,3-dione
INCHI	InChI=1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2
InChIKey	IDLAOWFFKWRNHB-UHFFFAOYSA-N
Smiles	C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
Isomeric SMILES	C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
PubChem CID	2729042
Molecular Weight	283.92

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
J2106095	Certificate of Analysis	Jul 08, 2024	T169439
J2106096	Certificate of Analysis	Jul 08, 2024	T169439
J2106097	Certificate of Analysis	Jul 08, 2024	T169439
J2106098	Certificate of Analysis	Jul 08, 2024	T169439

Chemical and Physical Properties

Solubility	DMSO: 5 mg/mL, clear
Molecular Weight	283.900 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	283.878 Da
Monoisotopic Mass	281.881 Da
Topological Polar Surface Area	34.100 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	289.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Shaowei Bo, Dong Zhang, Mengjie Ma, Xukai Mo, Julia Stabinska, Michael T. McMahon, Changzheng Shi, Liangping Luo. (2023) Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents. Pharmaceuticals, 16 (5): (639).
2. Wang Qian, He Yuan, Lu Rui, Wang Wen-Ming, Yang Ke-Wu, Fan Hai Ming, Jin Yi, Blackburn G. Michael. (2018) Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids. BIOSCIENCE REPORTS, 38 (2):
3. Guiying Zhu, Chaozheng Liu, Changli Zhang, Jiangtao Shi, Changtong Mei, Mingzhu Pan, Zhipeng Liu. (2024) Activating the Room-Temperature Phosphorescence of Organic Dyes through the Confinement Effect of Delignified Wood. ACS Sustainable Chemistry & Engineering, 12 (9): (3726-3735).
4. Binhao Wang, Yu Shen, Ruonan Hao, Shuheng Pan, Ruizhi Han, Ye Ni. (2025) Novel Approach for Efficient Separation of Primary Amines Using Supercritical Fluid Chromatography. CHIRALITY, 37 (1): (e70012).

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