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TC-E 5003 - 95%, high purity , CAS No.17328-16-4

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TC-E 5003 - 95%, high purity , CAS No.17328-16-4

COA

Grade & Purity:

≥95%

Cas Number: 17328-16-4
Molecular Weight: 401.26
PubChem CID: 87052
PubChem SID: 504755858

In stock

Item Number

T288605

Grouped product items
SKU	Size	Availability	Price
T288605-50mg	50mg	2	$165.90
T288605-100mg	100mg	2	$247.90
T288605-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$558.90

Selective PRMT1 inhibitor

View related series

Epigenetics (1496) Histone Methyltransferase (190) Histone Modification (1379)

Basic Description

Synonyms	N,N inverted exclamation mark -[Sulfonylbis(4,1-phenylene)]bis(2-chloroacetamide) \| A921688 \| 4-(2,2-DICHLOROACETAMIDO)PHENYL SULFONE \| AKOS024431411 \| N,N'-(Sulfonylbis(4,1-phenylene))bis(2-chloroacetamide) \| TC-E 5003 \| EINECS 285-652-6 \| N,N'-[Sulfonyl
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50= 1.5μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Anilides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Anilides
Intermediate Tree Nodes	Not available
Direct Parent	Anilides
Alternative Parents	Benzenesulfonyl compounds N-arylamides Sulfones Chloroacetamides Secondary carboxylic acid amides Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds Alkyl chlorides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Benzenesulfonyl group - Anilide - N-arylamide - Sulfone - Chloroacetamide - Sulfonyl - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Alkyl chloride - Organic nitrogen compound - Carbonyl group - Alkyl halide - Hydrocarbon derivative - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as anilides. These are organic heterocyclic compounds derived from oxoacids RkE(=O)l(OH)m (l not 0) by replacing an OH group by the NHPh group or derivative formed by ring substitution.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

LNCaP (8286 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SETD7 Tchem Histone-lysine N-methyltransferase SETD7 (390 Activities)

Discover Target: SETD7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRMT1 Tchem Protein-arginine N-methyltransferase 1 (867 Activities)

Discover Target: PRMT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504755858
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504755858
IUPAC Name	2-chloro-N-[4-[4-[(2-chloroacetyl)amino]phenyl]sulfonylphenyl]acetamide
INCHI	InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)
InChIKey	SHRCVZJKZJGIHQ-UHFFFAOYSA-N
Smiles	C1=CC(=CC=C1NC(=O)CCl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)CCl
Isomeric SMILES	C1=CC(=CC=C1NC(=O)CCl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)CCl
PubChem CID	87052
Molecular Weight	401.26

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
J2214406	Certificate of Analysis	Jun 02, 2022	T288605
J2214405	Certificate of Analysis	Jun 02, 2022	T288605
J2214385	Certificate of Analysis	Jun 02, 2022	T288605

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 20.06, Max Conc. mM: 50
Molecular Weight	401.300 g/mol
XLogP3	2.300
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	400.005 Da
Monoisotopic Mass	400.005 Da
Topological Polar Surface Area	101.000 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	519.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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