Compounds containing a pyrimidinylpiperazine skeleton, which consists of a pyrimidine linked (not fused) to a piperazine by a bond. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. Piperazine is a six-membered heterocyclic compound consisting of two nitrogen atoms and four carbon atoms.