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| Description | Receptor tyrosine-protein kinase erbB-2 |
|---|
Gene and Protein Information
| Gene ID | 2064 |
|---|---|
| Uniprot Accession IDs | P04626 B2RZG3 B4DHN3 Q14256 Q6LDV1 Q9UMK4 X5D2V5 |
| Ensembl ID | ENSG00000141736 |
| Symbol | HER2 MLN19 NEU NGL NEU NGL HER2 TKR1 CD340 HER-2 MLN 19 HER-2/neu |
| Chromosome | 17 |
| Family | Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. |
| Sequence |
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
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Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 454636 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | 9598 | VGNC:9276 | OMA, EggNOG |
| Macaque | 697573 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | 9544 | Inparanoid, OMA, EggNOG | |
| Mouse | 13866 | Erbb2 | erb-b2 receptor tyrosine kinase 2 | 10090 | MGI:95410 | Inparanoid, OMA, EggNOG |
| Rat | 24337 | Erbb2 | erb-b2 receptor tyrosine kinase 2 | 10116 | RGD:2561 | Inparanoid, OMA, EggNOG |
| Dog | 403883 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | 9615 | VGNC:40436 | Inparanoid, OMA, EggNOG |
| Horse | 100054739 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | 9796 | VGNC:17649 | Inparanoid, OMA, EggNOG |
| Cow | 505709 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | 9913 | VGNC:28563 | OMA, EggNOG |
| Pig | 100516641 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | 9823 | OMA, EggNOG | |
| Opossum | 100017172 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | 13616 | Inparanoid, OMA, EggNOG | |
| Anole lizard | 100565910 | erbb2 | erb-b2 receptor tyrosine kinase 2 | 28377 | Inparanoid, OMA | |
| Zebrafish | 386966 | erbb2 | erb-b2 receptor tyrosine kinase 2 | 7955 | ZDB-GENE-031118-121 | Inparanoid, OMA |
Protein Classes
DTO Classes
protein / Kinase / Protein kinase / TK group / EGFR family / Receptor tyrosine-protein kinase erbb-2
protein / Kinase / Protein kinase / TK group / EGFR family / Receptor tyrosine-protein kinase erbb-2
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Availability | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | Application | Availability | View Details |
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Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Direct Associated Targets | Disease Type | Mondoid |
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Bibliography
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