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TOP2A
| Description |
DNA topoisomerase 2-alpha
|
Gene and Protein Information
| Gene ID |
7153
|
| Uniprot Accession IDs |
P11388
B2RTS1
Q71UN1
Q71UQ5
Q9HB24
Q9HB25
Q9HB26
Q9UP44
Q9UQP9
|
| Ensembl ID |
ENSG00000131747
|
| Symbol |
TOP2
TOP2
TP2A
|
| Chromosome |
17
|
| Family |
Belongs to the type II topoisomerase family. |
| Sequence |
MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
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|
Homologous gene and protein info.
| Species |
Gene ID |
Gene Symbol |
Name |
Tax ID |
Other Gene ID |
Sources |
| Chimp |
454651 |
TOP2A |
DNA topoisomerase II alpha |
9598 |
VGNC:9732 |
Inparanoid, OMA, EggNOG |
| Mouse |
21973 |
Top2a |
topoisomerase (DNA) II alpha |
10090 |
MGI:98790 |
Inparanoid, OMA |
| Rat |
360243 |
Top2a |
DNA topoisomerase II alpha |
10116 |
RGD:62048 |
Inparanoid, OMA |
| Dog |
480525 |
TOP2A |
DNA topoisomerase II alpha |
9615 |
VGNC:49098 |
Inparanoid, OMA, EggNOG |
| Horse |
100054229 |
TOP2A |
DNA topoisomerase II alpha |
9796 |
VGNC:50516 |
Inparanoid, OMA, EggNOG |
| Cow |
787696 |
TOP2A |
DNA topoisomerase II alpha |
9913 |
VGNC:49583 |
Inparanoid, OMA, EggNOG |
| Pig |
396917 |
TOP2A |
DNA topoisomerase II alpha |
9823 |
|
Inparanoid, OMA, EggNOG |
| Opossum |
100016027 |
TOP2A |
DNA topoisomerase II alpha |
13616 |
|
Inparanoid, OMA, EggNOG |
| Platypus |
100090593 |
TOP2A |
DNA topoisomerase II alpha |
9258 |
|
Inparanoid, OMA, EggNOG |
| Chicken |
395570 |
TOP2A |
topoisomerase (DNA) II alpha |
9031 |
CGNC:49380 |
Inparanoid, OMA |
| Anole lizard |
100562686 |
top2a |
DNA topoisomerase II alpha |
28377 |
|
Inparanoid, OMA |
Associated Recombinant Proteins
| Name |
Specification and purity |
Expression system |
Protein label |
Availability |
View Details |
Associated Antibodies
| Name |
Specifications |
Species reactivity |
Application |
Availability |
View Details |
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name |
Direct Associated Targets |
Disease Type |
Mondoid |
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