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Targets(Human)
SIRT2

SIRT2

Description	NAD-dependent protein deacetylase sirtuin-2

Gene and Protein Information

Gene ID	22933
Uniprot Accession IDs	Q8IXJ6 A8K3V1 B2RB45 O95889 Q924Y7 Q9P0G8 Q9UNT0 Q9Y6E9 U5TP13
Ensembl ID	ENSG00000068903
Symbol	SIR2L SIR2L2 SIR2 SIR2L SIR2L2
Chromosome	19
Family	Belongs to the sirtuin family. Class I subfamily.
Sequence	MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	456013	SIRT2	sirtuin 2	9598	VGNC:12099	OMA, EggNOG
Macaque	100425019	SIRT2	sirtuin 2	9544		Inparanoid, OMA, EggNOG
Mouse	64383	Sirt2	sirtuin 2	10090	MGI:1927664	Inparanoid, OMA, EggNOG
Rat	361532	Sirt2	sirtuin 2	10116	RGD:621481	Inparanoid, OMA
Dog	612558	SIRT2	sirtuin 2	9615	VGNC:53983	Inparanoid, OMA, EggNOG
Horse	100146611	SIRT2	sirtuin 2	9796	VGNC:22987	Inparanoid, OMA, EggNOG
Cow	504463	SIRT2	sirtuin 2	9913	VGNC:34631	Inparanoid, OMA, EggNOG
Pig	100125964	SIRT2	sirtuin 2	9823		OMA, EggNOG
Anole lizard	100559366	sirt2	sirtuin 2	28377		Inparanoid, OMA
Xenopus	100489469	sirt2	sirtuin 2	8364	XB-GENE-987375	Inparanoid, OMA
Zebrafish	322309	sirt2	sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)	7955	ZDB-GENE-030131-1028	Inparanoid, OMA
S.cerevisiae	856092	HST2	histone deacetylase HST2	4932	S000005936	Inparanoid, OMA

Protein Classes

PANTHER Classes
protein / hydrolase / deacetylase / NAD-dependent protein deacetylase sirtuin-2
protein / hydrolase / chromatin/chromatin-binding protein / NAD-dependent protein deacetylase sirtuin-2

DTO Classes
protein / Epigenetic regulator / Eraser / Histone deacetylase / HDAC class III / NAD-dependent protein deacetylase sirtuin-2

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Availability	View Details

Associated Antibodies

Name	Specifications	Species reactivity	Application	Availability	View Details

Related active small molecules

AntibodiesProductName	Specification and purity	Mechanism Of Action	Availability	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Direct Associated Targets	Disease Type	Mondoid

Bibliography

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