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HMGCR

Description 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene and Protein Information

Gene ID 3156
Uniprot Accession IDs P04035 B7Z3Y9 Q8N190 HMG-CoA reductase
Ensembl ID ENSG00000113161
Symbol LDLCQ3
Chromosome 5
Family Belongs to the HMG-CoA reductase family.
Sequence
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
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Homologous gene and protein info.
Species Gene ID Gene Symbol Name Tax ID Other Gene ID Sources
Chimp 471516 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 9598 VGNC:4034 OMA, EggNOG
Macaque 705479 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 9544 Inparanoid, OMA, EggNOG
Mouse 15357 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 10090 MGI:96159 Inparanoid, OMA, EggNOG
Rat 25675 Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase 10116 RGD:2803 Inparanoid, OMA, EggNOG
Dog 479182 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 9615 VGNC:41714 Inparanoid, OMA, EggNOG
Horse 100065577 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 9796 VGNC:18807 Inparanoid, OMA, EggNOG
Cow 407159 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 9913 VGNC:29879 Inparanoid, OMA, EggNOG
Pig 100144446 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 9823 Inparanoid, OMA, EggNOG
Opossum 100014439 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 13616 Inparanoid, OMA, EggNOG
Platypus 100086613 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 9258 Inparanoid, OMA, EggNOG
Chicken 395145 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 9031 CGNC:11100 Inparanoid, OMA, EggNOG
Anole lizard 100555648 hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase 28377 Inparanoid, OMA, EggNOG
Xenopus 100380121 hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase 8364 XB-GENE-5840593 Inparanoid, OMA, EggNOG
Zebrafish 559054 hmgcra 3-hydroxy-3-methylglutaryl-CoA reductase a 7955 ZDB-GENE-040401-2 Inparanoid, OMA, EggNOG
C. elegans 176047 hmgr-1 3-hydroxy-3-methylglutaryl coenzyme A reductase 6239 Inparanoid, EggNOG
Fruitfly 42803 Hmgcr HMG Coenzyme A reductase 7227 FBgn0263782 Inparanoid, EggNOG
S.cerevisiae 851171 HMG2 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 4932 S000004442 Inparanoid, EggNOG

Associated Recombinant Proteins

Name Specification and purity Expression system Protein label Availability View Details

Associated Antibodies

Name Specifications Species reactivity Application Availability View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name Direct Associated Targets Disease Type Mondoid

Bibliography

🔙[Back to Target (Human)]

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