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Targets(Human)
PSEN1

PSEN1

Description	Presenilin-1

Gene and Protein Information

Gene ID	5663
Uniprot Accession IDs	P49768 B2R6D3 O95465 Q14762 Q15719 Q15720 Q96P33 Q9UIF0 PS-1
Ensembl ID	ENSG00000080815
Symbol	AD3 PS1 PSNL1 AD3 FAD PS1 PS-1 S182 ACNINV3
Chromosome	14
Family	Belongs to the peptidase A22A family.
Sequence	MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	739740	PSEN1	presenilin 1	9598	VGNC:3326	OMA, EggNOG
Macaque	696274	PSEN1	presenilin 1	9544		Inparanoid, OMA, EggNOG
Mouse	19164	Psen1	presenilin 1	10090	MGI:1202717	Inparanoid, OMA, EggNOG
Rat	29192	Psen1	presenilin 1	10116	RGD:3425	Inparanoid, OMA, EggNOG
Dog	403408	PSEN1	presenilin 1	9615	VGNC:45085	Inparanoid, OMA, EggNOG
Horse		PSEN1	presenilin 1 [Source:HGNC Symbol;Acc:HGNC:9508]	9796		OMA, EggNOG
Cow	282705	PSEN1	presenilin 1	9913	VGNC:33434	Inparanoid, OMA, EggNOG
Pig	780411	PSEN1	presenilin 1	9823		Inparanoid, OMA, EggNOG
Opossum	100019628	PSEN1	presenilin 1	13616		Inparanoid, EggNOG
Platypus	100091250	PSEN1	presenilin 1	9258		OMA, EggNOG
Chicken	373977	PSEN1	presenilin 1	9031	CGNC:7083	Inparanoid, OMA
Anole lizard	100553615	psen1	presenilin 1	28377		Inparanoid, OMA
Xenopus	394924	psen1	presenilin 1	8364	XB-GENE-481916	Inparanoid, OMA, EggNOG
Zebrafish	30221	psen1	presenilin 1	7955	ZDB-GENE-991119-4	Inparanoid, OMA
C. elegans	180441	sel-12	Presenilin sel-12	6239		OMA, EggNOG
Fruitfly	40260	Psn	Presenilin	7227	FBgn0019947	Inparanoid, EggNOG

Protein Classes

PANTHER Classes
protein    /    signaling molecule    /    membrane-bound signaling molecule    /    Presenilin-1
protein    /    signaling molecule    /    aspartic protease    /    Presenilin-1
protein    /    signaling molecule    /    protease    /    Presenilin-1
protein    /    signaling molecule    /    calcium-binding protein    /    Presenilin-1
protein    /    signaling molecule    /    hydrolase    /    Presenilin-1

DTO Classes
protein / Enzyme / Protease / Aspartic protease / Presenilin-1

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Availability	View Details

Associated Antibodies

Name	Specifications	Species reactivity	Application	Availability	View Details

Related active small molecules

AntibodiesProductName	Specification and purity	Mechanism Of Action	Availability	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Direct Associated Targets	Disease Type	Mondoid

Bibliography

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