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Sucralose granular - granular, Pharmaceutical grade, Ph. Eur., JPE, NF, high purity , CAS No.56038-13-2

23 Citations COA COA
In stock
Item Number
S432919
Grouped product items
SKU Size
Availability
 Price Qty
S432919-10g
10g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$156.90
S432919-50g
50g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$98.90
S432919-250g
250g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$245.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Disaccharide (89) Endogenous Metabolite (959) Metabolic Enzyme/Protease (4860) Metabolite (5307)

Basic Description

Synonyms Trichlorosucrose | Sucralose | E955 | 1-(1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl)-4-chloro-4-deoxy-α-D-galactopyranoside | 1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside
Specifications & Purity pharmaceutical grade, PharmPure™, Ph.Eur., JPE, granular
Biochemical and Physiological Mechanisms A synthetic sweet tastant detectable by humans. Activates T1R2/T1R3 sweet taste receptors on enteroendocrine cells and elicits increased hormonal secretion of Glukagon-like peptide-1 and glucose-dependent insulinotrophic peptide.
Storage Temp Room temperature
Shipped In Normal
Grade JPE, Ph.Eur., pharmaceutical grade, PharmPure™
Product Description

Sucralose is a high-intensity sweetener which is non-cariogenic and suitable for diabetics and patients with an impaired glucose tolerance. In addition, it is readily soluble and masks both bitterness and medicinal off-notes with equal ease – making it exceptionally well-suited for pharmaceutical applications. Our Sucralose is available in micronized or granular form, both pharmaceutical grade, allowing you to choose depending on your individual needs. Due to its optimal dispersion behavior, sucralose powder is typically recommended for solid dose formulations, while the fast dissolution behavior of sucralose granular makes it very well-suited for liquid formulations.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic oxygen compounds
Class Organooxygen compounds
Subclass Carbohydrates and carbohydrate conjugates
Intermediate Tree Nodes Glycosyl compounds
Direct Parent C-glycosyl compounds
Alternative Parents Ketals  Oxanes  Monosaccharides  Tetrahydrofurans  Secondary alcohols  Chlorohydrins  Oxacyclic compounds  Primary alcohols  Organochlorides  Hydrocarbon derivatives  Alkyl chlorides  
Molecular Framework Aliphatic heteromonocyclic compounds
Substituents C-glycosyl compound - Ketal - Oxane - Monosaccharide - Tetrahydrofuran - Secondary alcohol - Chlorohydrin - Halohydrin - Acetal - Oxacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organohalogen compound - Organochloride - Primary alcohol - Alkyl halide - Alkyl chloride - Alcohol - Aliphatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as c-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a C-glycosidic bond.
External Descriptors organochlorine compound - disaccharide derivative

Associated Targets(Human)

CA2 Tclin Carbonic anhydrase 2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TAS2R31 Tchem Taste receptor type 2 member 31 (86 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TAS2R10 Tchem Taste receptor type 2 member 10 (51 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK-293T (167025 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TAS2R46 Tchem Taste receptor type 2 member 46 (155 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
INCHI InChI=1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
InChIKey BAQAVOSOZGMPRM-QBMZZYIRSA-N
Smiles C(C1C(C(C(C(O1)OC2(C(C(C(O2)CCl)O)O)CCl)O)O)Cl)O
Isomeric SMILES C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CCl)O)O)CCl)O)O)Cl)O
WGK Germany 3
RTECS LW5440140
PubChem CID 71485
Molecular Weight 397.63
Beilstein 3654410
Reaxy-Rn 3654410

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Specific Rotation[α] 86.0° (C=1,H2O)
Melt Point(°C) 130°C
Molecular Weight 397.600 g/mol
XLogP3 -1.500
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 5
Exact Mass 396.015 Da
Monoisotopic Mass 396.015 Da
Topological Polar Surface Area 129.000 Ų
Heavy Atom Count 23
Formal Charge 0
Complexity 405.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 9
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

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    • 10mM in DMSO

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  2. Sucralose
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  3. Sucralose powder
    Sucralose powder

    Starting at $138.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Lingling Tian, Jingyan Shi, Wei Li, Yuan Zhang, Xinghua Gao.  (2023)  Hollow Microfiber Assembly-Based Endocrine Pancreas-on-a-Chip for Sugar Substitute Evaluation.  Advanced Healthcare Materials,    (2302104). 
2. He Yue, Chen Jianshe, Shi Weiyao, Shi Jingang, Ma Tian, Wang Xinmiao.  (2023)  Can nonvolatile tastants be smelled during food oral processing?.  CHEMICAL SENSES,  48   
3. Zhang Yuntao, Liu Lin, Wei Chunbo, Wang Xuanyang, Li Ran, Xu Xiaoqing, Zhang Yingfeng, Geng Guannan, Dang Keke, Ming Zhu, Tao Xinmiao, Xu Huan, Yan Xuemin, Zhang Jia, Hu Jinxia, Li Ying.  (2023)  Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.  BMC Medicine,  21  (1): (1-16). 
4. Xue Mei, Wenchang Wang, Qingyi Li, Minxian Wu, Liyin Bu, Zhidong Chen.  (2023)  A novel electrochemical sensor based on gold nanobipyramids and poly-L-cysteine for the sensitive determination of trilobatin.  ANALYST,  148  (10): (2335-2342). 
5. Xuejiao Zhang, Jiaxin Gu, Congying Zhao, Yaozhong Hu, Bowei Zhang, Jin Wang, Huan Lv, Xuemeng Ji, Shuo Wang.  (2022)  Sweeteners Maintain Epithelial Barrier Function Through the miR-15b/RECK/MMP-9 Axis, Remodel Microbial Homeostasis, and Attenuate Dextran Sodium Sulfate-Induced Colitis in Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (1): (171–183). 
6. Xiaofeng Wei, Ying Chen, Shan He, Huiting Lian, Xuegong Cao, Bin Liu.  (2021)  L-histidine-regulated zeolitic imidazolate framework modified electrochemical interface for enantioselective determination of L-glutamate.  ELECTROCHIMICA ACTA,  400  (139464). 
7. Ferry Saputra, Yu-Heng Lai, Rey Arturo T. Fernandez, Allan Patrick G. Macabeo, Hong-Thih Lai, Jong-Chin Huang, Chung-Der Hsiao.  (2021)  Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae.  Biology-Basel,  10  (6): (548). 
8. Pingping Cui, Qiuxiang Yin, Shihao Zhang, Xiaowei Cheng, Jiayu Dai, Zaixiang Zhang, Ling Zhou, Chuang Xie.  (2020)  The effect of solvents on crystal morphology of sucralose: Experiments and molecular dynamics simulation studies.  JOURNAL OF CRYSTAL GROWTH,  532  (125398). 
9. Yong Li, Tingting Yang, Qing Yao, Songsong Li, En Fang, Yankun Li, Chao Liu, Weimin Li.  (2019)  Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats.  NEUROGASTROENTEROLOGY AND MOTILITY,  31  (5): (e13556). 
10. Yin Xu, Ying Wu, Wei Zhang, Xiaohui Fan, Yan Wang, Hui Zhang.  (2018)  Performance of artificial sweetener sucralose mineralization via UV/O3 process: Kinetics, toxicity and intermediates.  CHEMICAL ENGINEERING JOURNAL,  353  (626). 
11. Hongmei Zhang, Shixin Sun, Yanqing Wang, Zhenghao Fei, Jian Cao.  (2018)  Binding mechanism of five typical sweeteners with bovine serum albumin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  205  (40). 
12. Hongmei Zhang, Shixin Sun, Yanqing Wang, Jian Cao.  (2017)  Interaction of sucralose with whey protein: Experimental and molecular modeling studies.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  187  (92). 
13. Jiang Ting-Fu, Chong Lei, Yue Mei-E, Wang Yuan-Hong, Lv Zhi-Hua.  (2015)  Separation and Determination of Carbohydrates in Food Samples by Capillary Electrophoresis Using Dynamically Coating the Capillary with Indirect UV Detection.  Food Analytical Methods,  8  (10): (2588-2594). 
14. Longmei Yao, Xue Mei, Jiajia Zhi, Wenchang Wang, Qingyi Li, Ding Jiang, Xiaohui Chen, Zhidong Chen.  (2024)  A novel electrochemiluminescent sensor based on AgMOF@N-CD composites for sensitive detection of trilobatin.  ANALYST,     
15. Dali Zhuo, Xiaoyu Dong, Linghuan Li, Ronghua Zeng, Chao Tan, Hong Luo, Zhirong Zou.  (2025)  Detection of Ca2+ in water samples and calcium gluconate oral liquids using gas pressure meter as portable detector.  MICROCHEMICAL JOURNAL,    (113116). 
16. Jingyan Shi, Jianing Li, Wentao Su, Chang Xue, Yuan Zhang, Xinghua Gao.  (2024)  Engineered microenvironments and pancreatic islet-on-chips for screening sugar substitute and antidiabetic compounds.  FOOD RESEARCH INTERNATIONAL,  196  (115084). 
17. Li Hao, Du Yu, Cheng Kaiwen, Chen Yuxi, Wei Ling, Pei Yujun, Wang Xiaoyu, Wang Lan, Zhang Ye, Hu Xiaoxin, Lu Yi, Zhu Xiangjia.  (2024)  Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis.  Cell Discovery,  10  (1): (1-14). 
18. Li Zhang, Lei Feng, Lin Yang, Hao Wan.  (2025)  Noninvasive Detection and Monitoring of the Integrity of the Intestinal Barrier through NIR-II Fluorescence Imaging and Colorimetric Urinalysis.  ACS Applied Materials & Interfaces,     
19. Zizhang Wang, Hao Li, Yuxiang Weng.  (2024)  OsFKBP12 transduces the sucrose signal from OsNIN8 to the OsTOR pathway in a loosely binding manner for cell division.  iScience,     
20. Yue He, Jianshe Chen, Weiyao Shi, Jingang Shi.  (2024)  Retronasal sensation of nonvolatile sweeteners and its impacts on the flavor perception of beverages.  FOOD QUALITY AND PREFERENCE,  115  (105107). 
21. Jing Xiao, Dali Zhuo, Jiayuan Tang, Jihong Chen, Chao Tan, Shu Zhang, Shichao Li, Zhirong Zou.  (2024)  Selective and sensitive detection of cyclamate in beverages using a portable pressure meter: A specific reaction-based analytical kit.  MICROCHEMICAL JOURNAL,  204  (110959). 
22. Luyao Yang, Shuangshuang Wang, Jing Jin, Jiahui Wang, Wenyue Chen, Yun Xue, Liang Sheng, Yongning Zhai, Weifeng Yao.  (2024)  Sucralose triggers insulin resistance leading to follicular dysplasia in mice.  REPRODUCTIVE TOXICOLOGY,  128  (108644). 
23. Wenjiao Liu, Han wang, Qi Mu, Ting Gong.  (2024)  Taste receptor T1R3 regulates testosterone synthesis via the cAMP-PKA-SP1 pathway in testicular Leydig cells.  THERIOGENOLOGY,     

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